R
Rong Tan
Researcher at Central South University
Publications - 8
Citations - 422
Rong Tan is an academic researcher from Central South University. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 4, co-authored 4 publications receiving 244 citations. Previous affiliations of Rong Tan include University of Pittsburgh.
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Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
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Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Chen Wang,Huanyin Tang,Anke Geng,Binghua Dai,Haiping Zhang,Xiaoxiang Sun,Yu Chen,Zhibing Qiao,Hong Zhu,Jiamei Yang,Jiayu Chen,Qizhi He,Nan Qin,Jinru Xie,Rong Tan,Xiaoping Wan,Shaorong Gao,Ying Jiang,Fang-Lin Sun,Zhiyong Mao +19 more
TL;DR: It is demonstrated that both DSB repair pathways are up-regulated in hepatocellular carcinoma (HCC) compared with adjacent normal tissues due to altered expression of DNA repair factors, including PARP1 and DNA-PKcs.
Journal ArticleDOI
POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions.
Yang Yu,Rong Tan,Qian Ren,Boya Gao,Zhejin Sheng,Juanlian Zhang,Xiaoqing Zheng,Ying Jiang,Li Lan,Zhiyong Mao,Zhiyong Mao +10 more
TL;DR: Mechanistic studies indicate that POT1 facilitates the recruitment of Artemis, which is a nuclease and promotes fidelity of NHEJ, to DNA damage sites, and overexpression of POT2 inhibits the protein stability of Lig3, therefore suppressing the efficiency of alt-NHEJ.
Journal ArticleDOI
Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.
Haiping Zhang,Bailian Cai,Anke Geng,Huanyin Tang,Wenjun Zhang,Sheng Li,Ying Jiang,Rong Tan,Xiaoping Wan,Zhiyong Mao,Zhiyong Mao +10 more
TL;DR: In this article, the authors compared the efficiency of base excision repair (BER) and two DNA double-strand break (DSB) repair pathways-nonhomologous end joining (NHEJ) and homologous recombination (HR)-between the young and old groups.
Journal ArticleDOI
The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies.
Jinru Xie,Ming Wen,Jiao Zhang,Zheng Wang,Meng Wang,Yanfang Qiu,Wen Ke Zhao,Fang Zhu,Mianfeng Yao,Zhuo-Xian Rong,Wen Fang Hu,Qian Pei,Xiaoxiang Sun,Jinchen Li,Zhiyong Mao,Lun-Quan Sun,Rong Tan +16 more
TL;DR: The role ofRNA helicases in DNA damage and their associations with cancer, which could expand therapeutic strategies and improve precision treatments for cancer patients with high expression of RNA helicases are revealed.