T
Tianqi Tang
Researcher at Tongji University
Publications - 5
Citations - 473
Tianqi Tang is an academic researcher from Tongji University. The author has contributed to research in topics: Innate immune system & Proinflammatory cytokine. The author has an hindex of 4, co-authored 5 publications receiving 284 citations.
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Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
Journal ArticleDOI
Host-mediated ubiquitination of a mycobacterial protein suppresses immunity
Lin Wang,Juehui Wu,Jun Li,Hua Yang,Tianqi Tang,Haijiao Liang,Mianyong Zuo,Jie Wang,Haipeng Liu,Feng Liu,Jianxia Chen,Zhonghua Liu,Yang Wang,Cheng Peng,Xiangyang Wu,Ruijuan Zheng,Xiaochen Huang,Yajun Ran,Zihe Rao,Baoxue Ge +19 more
TL;DR: This work reports that the host E3 ubiquitin ligase ANAPC2—a core subunit of the anaphase-promoting complex/cyclosome—interacts with the mycobacterial protein Rv0222 and promotes the attachment of lysine-11-linked ubiquit in chains to lysin 76 of Rv 0222 in order to suppress the expression of proinflammatory cytokines.
Journal ArticleDOI
Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis
Hua Yang,Wei Sha,Zhonghua Liu,Tianqi Tang,Haipeng Liu,Lianhua Qin,Zhen-ling Cui,Jianxia Chen,Feng Liu,Ruijuan Zheng,Xiaochen Huang,Jie Wang,Yonghong Feng,Baoxue Ge +13 more
TL;DR: It is suggested that hypoxia induces the deacetylation of DosR, which in turn increases its DNA-binding ability to promote the transcription of target genes, allowing Mtb to shift to dormancy under Hypoxia.
Journal ArticleDOI
Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis.
Lin Wang,Zhonghua Liu,Jie Wang,Haipeng Liu,Juehui Wu,Tianqi Tang,Haohao Li,Hua Yang,Lianhua Qin,Dapeng Ma,Jianxia Chen,Feng Liu,Peng Wang,Ruijuan Zheng,Peng Song,Yilong Zhou,Zhenling Cui,Xiangyang Wu,Xiaochen Huang,Haijiao Liang,Shanshan Zhang,Jingjing Cao,Chunyan Wu,Yiping Chen,Dan Su,Xinchun Chen,Gucheng Zeng,Baoxue Ge +27 more
TL;DR: It is reported that MPT53 (Rv2878c), a secreted disulfide-bond-forming-like protein of Mtb, directly interacts with TGF-β-activated kinase 1 (TAK1) and activates TAK1 in a TLR2- or MyD88-independent manner and induces the host immune inflammatory response.
Journal ArticleDOI
Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity.
Hua Yang,Fei Wang,Guo Xinya,Feng Liu,Zhonghua Liu,Xiangyang Wu,Mengmeng Zhao,Mingtong Ma,Haipeng Liu,Lianhua Qin,Lin Wang,Tianqi Tang,Wei Sha,Yang Wang,Jianxia Chen,Xiaochen Huang,Jie Wang,Cheng Peng,Ruijuan Zheng,Fen Tang,Lu Zhang,Chunyan Wu,Stefan H. Oehlers,Zhigang Song,Jialei She,Hua Feng,Xunwei Xie,Baoxue Ge +27 more
TL;DR: In this article, the authors found that mycobacteria under hypoxia markedly secrete the protein Rv0859/MMAR_4677 (Fatty acid degradation A, FadA), which is also enriched in tuberculous granulomas.