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Dapeng Ma
Researcher at Tongji University
Publications - 5
Citations - 410
Dapeng Ma is an academic researcher from Tongji University. The author has contributed to research in topics: Gene & Cancer research. The author has an hindex of 3, co-authored 3 publications receiving 246 citations.
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Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
Journal ArticleDOI
Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.
Ruijuan Zheng,Haipeng Liu,Yilong Zhou,Dapeng Yan,Jianxia Chen,Dapeng Ma,Yonghong Feng,Lianhua Qin,Feng Liu,Xiaochen Huang,Jie Wang,Baoxue Ge +11 more
TL;DR: It is found that Notch4-deficient mice were more resistant to M. tuberculosis infection, with a much lower bacterial burden and fewer pathological changes in the lungs, and treatment with a Notch inhibitor could serve as a new therapeutic strategy for tuberculosis.
Journal ArticleDOI
Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis.
Lin Wang,Zhonghua Liu,Jie Wang,Haipeng Liu,Juehui Wu,Tianqi Tang,Haohao Li,Hua Yang,Lianhua Qin,Dapeng Ma,Jianxia Chen,Feng Liu,Peng Wang,Ruijuan Zheng,Peng Song,Yilong Zhou,Zhenling Cui,Xiangyang Wu,Xiaochen Huang,Haijiao Liang,Shanshan Zhang,Jingjing Cao,Chunyan Wu,Yiping Chen,Dan Su,Xinchun Chen,Gucheng Zeng,Baoxue Ge +27 more
TL;DR: It is reported that MPT53 (Rv2878c), a secreted disulfide-bond-forming-like protein of Mtb, directly interacts with TGF-β-activated kinase 1 (TAK1) and activates TAK1 in a TLR2- or MyD88-independent manner and induces the host immune inflammatory response.
Journal ArticleDOI
The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
Xiaomin Ma,Xiaoxiao Ma,Lihui Zhu,Yunxue Zhao,Meng-Meng Chen,Tao Li,Yueke Lin,Dapeng Ma,Caiyu Sun,Lihui Han +9 more
TL;DR: Wang et al. as mentioned in this paper demonstrated that E3 ubiquitin ligase MG53 (also known as tripartite motif 72, TRIM72) acted as a direct inhibitor of RAC1, and it catalyzed the ubiquitination and further inhibited RAC 1 activity in HCC cells.
Journal ArticleDOI
cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway.
Xuecheng Shen,Caiyu Sun,Yeping Cheng,Dapeng Ma,Yanlin Sun,Yueke Lin,Yunxue Zhao,Min Yang,Weiqiang Jing,Xiuling Cui,Lihui Han +10 more
TL;DR: In this paper , the role of cyclic GMP-AMP synthase (cGAS) in macrophage polarization during inflammation was investigated, and it was shown that deletion of Cgas alleviated sepsis-induced acute lung injury by promoting macrophages to shift from the M1 phenotype to the M2 phenotype.