Roni Nowarski

TL;DR: It is proposed that understanding this microbial influence will be crucial for targeted therapy in modern cancer treatment and the recently suggested role of commensal microorganisms in inflammation-induced cancer is discussed.

TL;DR: It is demonstrated that the NLRP6 inflammasome, a recently described regulator of colonic microbiota composition and biogeographical distribution, is a critical orchestrator of goblet cell mucin granule exocytosis, linking nonhematopoietic inflammaome signaling to autophagy and highlighting the gobleT cell as a critical innate immune player in the control of intestinal host-microbial mutualism.

TL;DR: It is shown that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis, and the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis is informed on.

TL;DR: An aptamer-based machine is used for the amplified detection of the low-molecular-weight analyte, cocaine, and a polymerization-nicking and strand displacement is initiated on the cocaine−aptamer complex that acts as “track”.