R
Rork Kuick
Researcher at University of Michigan
Publications - 166
Citations - 17557
Rork Kuick is an academic researcher from University of Michigan. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 60, co-authored 166 publications receiving 16459 citations. Previous affiliations of Rork Kuick include University of Florida.
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Journal ArticleDOI
Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles
Thomas J. Giordano,Kerby Shedden,Donald R. Schwartz,Rork Kuick,Jeremy M. G. Taylor,Nana Lee,David E. Misek,Joel K. Greenson,Sharon L.R. Kardia,David G. Beer,Gad Rennert,Kathleen R. Cho,Stephen B. Gruber,Eric R. Fearon,Samir M. Hanash +14 more
TL;DR: The ability of gene expression profiles to classify tumors is demonstrated and determination of organ-specific gene Expression profiles will play a significant role in a wide variety of clinical settings, including molecular diagnosis and classification is suggested.
Journal ArticleDOI
Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion.
Yali Zhai,Rork Kuick,Bin Nan,Ichiro Ota,Stephen J. Weiss,Cornelia L. Trimble,Eric R. Fearon,Kathleen R. Cho +7 more
TL;DR: Findings support a key role for the HOXC10 homeobox protein in cervical cancer progression and suggest other genes with differential expression in invasive SCC versus HSIL may contribute to tumor progression or may be useful as markers for cancer diagnosis or progression risk.
Journal ArticleDOI
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia
TL;DR: CDX2 regulates LI-cadherin gene expression in normal, metaplastic, and neoplastic tissues of the gastrointestinal tract via binding to elements in the 5'-flanking region of the gene.
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Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis
Weimin Gao,Weimin Gao,Rork Kuick,Randal P. Orchekowski,David E. Misek,Ji Qiu,Ji Qiu,Alissa K. Greenberg,William N. Rom,Dean E. Brenner,Gilbert S. Omenn,Brian B. Haab,Samir M. Hanash,Samir M. Hanash +13 more
TL;DR: The results suggest that a distinctive serum protein profile involving abundant proteins may be observed in lung cancer patients relative to healthy subjects or patients with chronic disease and may have utility as part of strategies for detecting lung cancer.
Journal ArticleDOI
Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma
Ferdous M. Barlaskar,Aaron C. Spalding,Joanne H. Heaton,Rork Kuick,Alex C. Kim,Dafydd G. Thomas,Thomas J. Giordano,Edgar Ben-Josef,Gary D. Hammer +8 more
TL;DR: Findings establish a critical role of IGF signaling in ACC pathophysiology and provide rationale for use of targeted IGF-1R antagonists to treat adrenocortical carcinoma in future clinical trials.