R
Rork Kuick
Researcher at University of Michigan
Publications - 166
Citations - 17557
Rork Kuick is an academic researcher from University of Michigan. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 60, co-authored 166 publications receiving 16459 citations. Previous affiliations of Rork Kuick include University of Florida.
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Journal ArticleDOI
ICF, An Immunodeficiency Syndrome: DNA Methyltransferase 3B Involvement, Chromosome Anomalies, and Gene Dysregulation
Melanie Ehrlich,Cecilia G. Sanchez,Chunbo Shao,Rie Nishiyama,John H. Kehrl,Rork Kuick,Takeo Kubota,Samir M. Hanash +7 more
TL;DR: It is proposed that hypomethylation of satellite 2 at 1qh and 16qh might provoke this dysregulation gene expression by trans effects from altered sequestration of transcription factors, changes in nuclear architecture, or expression of noncoding RNAs.
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Development of Natural Protein Microarrays for Diagnosing Cancer Based on an Antibody Response to Tumor Antigens
Ji Qiu,Juan Madoz-Gurpide,David E. Misek,Rork Kuick,Dean E. Brenner,George Michailidis,Brian B. Haab,Gilbert S. Omenn,Samir M. Hanash +8 more
TL;DR: The reproducibility of natural protein microarrays is assessed and their ability to distinguish between lung cancer sera and controls is assessed, providing the means for uncovered a repertoire of tumor antigens that have induced an antibody response in patients with specific cancers.
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Delineation, Functional Validation, and Bioinformatic Evaluation of Gene Expression in Thyroid Follicular Carcinomas with the PAX8-PPARG Translocation
Thomas J. Giordano,Amy Y. M. Au,Rork Kuick,Dafydd G. Thomas,Daniel R. Rhodes,Kenneth G. Wilhelm,Michelle Vinco,David E. Misek,Donita Sanders,Zhaowen Zhu,Raffaele Ciampi,Samir M. Hanash,Arul M. Chinnaiyan,Roderick J. Clifton-Bligh,Bruce G. Robinson,Yuri E. Nikiforov,Ronald J. Koenig +16 more
TL;DR: Bioinformatics analyses revealed that genes with increased expression in PPFP-positive follicular carcinomas include known PPAR target genes; genes involved in fatty acid, amino acid, and carbohydrate metabolism; micro-RNAtarget genes; and genes on chromosome 3p.
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Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
Kerby Shedden,Wei Chen,Rork Kuick,Debashis Ghosh,James W. MacDonald,Kathleen R. Cho,Thomas J. Giordano,Stephen B. Gruber,Eric R. Fearon,Jeremy M. G. Taylor,Samir M. Hanash +10 more
TL;DR: Choice of processing method has a major impact on differential expression analysis of microarray data and performance of array processing methods in disease profiling and other realistic biological studies should be given greater consideration when comparing Affymetrix processing methods.
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A novel amplicon at 8p22–23 results in overexpression of cathepsin B in esophageal adenocarcinoma
Steven J. Hughes,Thomas W. Glover,Xiao-Xiang Zhu,Rork Kuick,Didier Thoraval,Mark B. Orringer,David G. Beer,Samir M. Hanash +7 more
TL;DR: The finding of an amplicon at 8p22-23 resulting in CTSB gene amplification and overexpression supports an important role for C TSB in esophageal adenocarcinoma and possibly in other tumors.