Rork Kuick

TL;DR: The results suggest that HOX protein-protein interactions without direct HOX DNA-binding may play a larger role in HOX transcriptional regulation than generally assumed, and DNA- binding appears critical for repression.

TL;DR: Dax1 plays an important role in the maintenance of pluripotency in mES cells through interaction with LRH-1 and transcriptional activation of Oct4 and other genes.

TL;DR: Studies of this type allow us to examine the specific contribution of cancer cells to gene expression patterns within an in vivo tumor mixed with non-cancerous tissue.

TL;DR: In vivo administration of the histone methylation inhibitor 3-deazaneplanocin A (DZNep) arrests ongoing GVHD in mice after allogeneic BM transplantation and preserves the antileukemia activity of donor T cells and did not impair the recovery of hematopoiesis and lymphocytes, leading to significantly improved survival of recipients after allogenicic BM transplation.

TL;DR: The occurrence of significant intra-tumor heterogeneity in rectal cancers involving variations in localized somatic mutations and copy number abnormalities may allow selected tumors to have a genetic reservoir to draw from in their evolutionary response to therapy and other challenges.