R
Rosella Mechelli
Researcher at Sapienza University of Rome
Publications - 49
Citations - 1811
Rosella Mechelli is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Multiple sclerosis & Population. The author has an hindex of 20, co-authored 45 publications receiving 1589 citations.
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Journal ArticleDOI
Viruses and neuroinflammation in multiple sclerosis
Rosella Mechelli,Carmela Romano,Roberta Reniè,Grazia Manfrè,Maria Chiara Buscarinu,Silvia Romano,Antonio Marrone,Rachele Bigi,Gianmarco Bellucci,Chiara Ballerini,Benedetta Angeloni,Virginia Rinaldi,Marco Salvetti,Giovanni Ristori +13 more
TL;DR: The aim of this work is to contribute towards the humanizing of neuroscience and the promotion of quality of life through research and clinical practice.
Journal ArticleDOI
Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients.
Viviana Annibali,Renato Umeton,Antonia Palermo,Martina Severa,Marilena P. Etna,Simona Giglio,Silvia Romano,Michela Ferraldeschi,Maria Chiara Buscarinu,Andrea Vecchione,Anita Annese,Claudia Policano,Rosella Mechelli,Raffaella Pizzolato Umeton,Arianna Fornasiero,Daniela F. Angelini,Gisella Guerrera,Luca Battistini,Eliana M. Coccia,Marco Salvetti,Giovanni Ristori +20 more
TL;DR: In this paper, the authors performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls and found that IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients.
Journal ArticleDOI
Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain
Francesca Gargano,Gisella Guerrera,Eleonora Piras,Barbara Serafini,Monica Di Paola,Lisa Rizzetto,Maria Chiara Buscarinu,Viviana Annibali,Claudia Vuotto,Marco De Bardi,Silvia D'Orso,Serena Ruggieri,Claudio Gasperini,Lorenzo Pavarini,Giovanni Ristori,Mario Picozza,Barbara Rosicarelli,Clara Ballerini,Rosella Mechelli,Francesco Vitali,Duccio Cavalieri,Marco Salvetti,Daniela F. Angelini,Giovanna Borsellino,Carlotta De Filippo,Luca Battistini +25 more
TL;DR: Results were in agreement with the hypothesis that dysbiosis of the gut microbiota might determine the inappropriate response of a subset of pathogenic mucosal T cells and favor the development of systemic inflammatory and autoimmune diseases.
Journal ArticleDOI
Drug Holiday of Interferon Beta 1b in Multiple Sclerosis: A Pilot, Randomized, Single Blind Study of Non-inferiority
Silvia Romano,Michela Ferraldeschi,Francesca Bagnato,Rosella Mechelli,Emanuele Morena,Marzia Caldano,Maria Chiara Buscarinu,Arianna Fornasiero,M. Frontoni,Viviana Nociti,Massimiliano Mirabella,Flavia Mayer,Antonio Bertolotto,Carlo Pozzilli,Nicola Vanacore,Marco Salvetti,Giovanni Ristori +16 more
TL;DR: A calendar with CW was non-inferior than FR at the beginning of IFN-b therapy, and may not affect the long-term outcome, as compared with a calendar with FR.
Journal ArticleDOI
Antiviral immune response in patients with multiple sclerosis, healthy siblings and twins.
Giovanni Ristori,Rosella Mechelli,Jourdan Anderson,Fabio Mengoni,Ilaria Sauzullo,Viviana Annibali,Stefania Cannoni,Francesca Aloisi,Judith A. James,Marco Salvetti +9 more
TL;DR: The association between MS status and EBV serology that emerged in some of the tests that have performed should not be overlooked, also considering the lack of substantial genetic, epigenetic and transcriptome variations in identical twins discordant for MS.