R
Rosemary Grabs
Researcher at McGill University
Publications - 4
Citations - 353
Rosemary Grabs is an academic researcher from McGill University. The author has contributed to research in topics: Diabetes mellitus genetics & Gene. The author has an hindex of 4, co-authored 4 publications receiving 325 citations.
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Journal ArticleDOI
Rfx6 directs islet formation and insulin production in mice and humans
Stuart Smith,Hui-Qi Qu,Nadine Taleb,Nina Kishimoto,David W. Scheel,Yang Lu,Ann-Marie Patch,Rosemary Grabs,Juehu Wang,Francis C. Lynn,Francis C. Lynn,Takeshi Miyatsuka,John J. Mitchell,Rina Seerke,Julie Désir,Serge Vanden Eijnden,Marc Abramowicz,Nadine Kacet,Jacques Weill,Marie Éve Renard,Mattia Gentile,Inger Hansen,Ken Dewar,Andrew T. Hattersley,Rennian Wang,Maria E. Wilson,Jeffrey D. Johnson,Constantin Polychronakos,Michael S. German +28 more
TL;DR: It is shown that the transcription factor Rfx6 directs islet cell differentiation downstream of Neurog3, a unique position for RFX6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans.
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A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.
TL;DR: Comparing IGF2 expression levels from chromosomes with the protective class III alleles to those with class I alleles in tissues relevant to type 1 diabetes pathogenesis found no significant difference, evidence against the hypotheses that have suggested IGF2 is a mediator of IDDM2-encoded susceptibility and corroborates previous studies suggesting insulin is the gene involved.
Journal ArticleDOI
The IRF5 polymorphism in type 1 diabetes
TL;DR: The results suggest that the functional IRF5 variations do not confer an obvious risk for type 1 diabetes, and may also predispose to other autoimmune disorders.
Journal ArticleDOI
Familial clustering strongly suggests that the phenotypic variation of the 8344 A>G lys mitochondrial tRNA mutation is encoded in cis.
Kyriakos Kazakos,Kalliopi Kotsa,Maria P. Yavropoulou,Alexander Dionyssopoulos,Rosemary Grabs,John G. Yovos,Constantin Polychronakos +6 more
TL;DR: A large kindred with a statistically significant clustering of very unusual clinical manifestations of myoclonic epilepsy, ragged‐red muscle fiber syndrome and multiple lipomatosis is reported.