H
Hui-Qi Qu
Researcher at Children's Hospital of Philadelphia
Publications - 104
Citations - 4121
Hui-Qi Qu is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 29, co-authored 104 publications receiving 3584 citations. Previous affiliations of Hui-Qi Qu include Montreal Children's Hospital & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
Hakon Hakonarson,Struan F.A. Grant,Jonathan P. Bradfield,Luc Marchand,Cecilia E. Kim,Joseph T. Glessner,Rosemarie Grabs,Tracy Casalunovo,Shayne Taback,Edward Frackelton,Margaret L. Lawson,Luke J. Robinson,Robert Skraban,Yang Lu,Rosetta M. Chiavacci,Charles A. Stanley,Susan E. Kirsch,Eric F. Rappaport,Jordan S. Orange,Dimitri S. Monos,Dimitri S. Monos,Marcella Devoto,Hui-Qi Qu,Constantin Polychronakos +23 more
TL;DR: It is found that T1D was significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that contains KIAA0350, the gene product of which is predicted to be a sugar-binding, C-type lectin.
Journal ArticleDOI
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
Jonathan P. Bradfield,Hui-Qi Qu,Kai Wang,Haitao Zhang,Patrick M. A. Sleiman,Cecilia E. Kim,Frank D. Mentch,Haijun Qiu,Joseph T. Glessner,Kelly A. Thomas,Edward C. Frackelton,Rosetta M. Chiavacci,Marcin Imielinski,Dimitri S. Monos,Dimitri S. Monos,Rahul Pandey,Marina Bakay,Struan F.A. Grant,Struan F.A. Grant,Constantin Polychronakos,Hakon Hakonarson,Hakon Hakonarson +21 more
TL;DR: Targeted follow-up of 53 SNPs in 1,120 affected trios uncovered three new loci associated with T1D that reached genome-wide significance, and these latest associated regions add to the growing repertoire of gene networks predisposing to type 1 diabetes.
Journal ArticleDOI
Rfx6 directs islet formation and insulin production in mice and humans
Stuart Smith,Hui-Qi Qu,Nadine Taleb,Nina Kishimoto,David W. Scheel,Yang Lu,Ann-Marie Patch,Rosemary Grabs,Juehu Wang,Francis C. Lynn,Francis C. Lynn,Takeshi Miyatsuka,John J. Mitchell,Rina Seerke,Julie Désir,Serge Vanden Eijnden,Marc Abramowicz,Nadine Kacet,Jacques Weill,Marie Éve Renard,Mattia Gentile,Inger Hansen,Ken Dewar,Andrew T. Hattersley,Rennian Wang,Maria E. Wilson,Jeffrey D. Johnson,Constantin Polychronakos,Michael S. German +28 more
TL;DR: It is shown that the transcription factor Rfx6 directs islet cell differentiation downstream of Neurog3, a unique position for RFX6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans.
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Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients.
Hai Qiong Yu,Bao qing Sun,Zhangfu Fang,Jin Cun Zhao,Xiaoyu Liu,Yimin Li,Xi Zhuo Sun,Hong Feng Liang,Bei Zhong,Zhifeng Huang,Pei Yan Zheng,Lifeng Tian,Hui-Qi Qu,De Chen Liu,Er Yi Wang,Xiao Jun Xiao,Shi Yue Li,Feng Ye,Li Guan,Dongsheng Hu,Hakon Hakonarson,Hakon Hakonarson,Zhigang Liu,Nanshan Zhong +23 more
TL;DR: Humoral immune response to SARS-CoV-2 showed an early response of IgA, instead of IgM, in COVID-19 patients, suggesting enhanced IgA responses observed in severe CO VID-19 might confer damaging effects in severeCOVID- 19.
Journal ArticleDOI
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes.
Zhi Wei,Kai Wang,Hui-Qi Qu,Haitao Zhang,Jonathan P. Bradfield,Cecilia Kim,Edward Frackleton,Cuiping Hou,Joseph T. Glessner,Rosetta M. Chiavacci,Charles A. Stanley,Dimitri S. Monos,Struan F.A. Grant,Constantin Polychronakos,Hakon Hakonarson +14 more
TL;DR: It is suggested that improved disease risk assessment can be achieved by using algorithms that take into account interactions between a large ensemble of markers, especially for diseases where a notable proportion of the risk has already been captured by SNP arrays.