Y
Yang Lu
Researcher at University of Texas Health Science Center at Houston
Publications - 13
Citations - 1044
Yang Lu is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Population & Gene. The author has an hindex of 10, co-authored 13 publications receiving 973 citations. Previous affiliations of Yang Lu include McGill University & Montreal Children's Hospital.
Papers
More filters
Journal ArticleDOI
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
Hakon Hakonarson,Struan F.A. Grant,Jonathan P. Bradfield,Luc Marchand,Cecilia E. Kim,Joseph T. Glessner,Rosemarie Grabs,Tracy Casalunovo,Shayne Taback,Edward Frackelton,Margaret L. Lawson,Luke J. Robinson,Robert Skraban,Yang Lu,Rosetta M. Chiavacci,Charles A. Stanley,Susan E. Kirsch,Eric F. Rappaport,Jordan S. Orange,Dimitri S. Monos,Dimitri S. Monos,Marcella Devoto,Hui-Qi Qu,Constantin Polychronakos +23 more
TL;DR: It is found that T1D was significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that contains KIAA0350, the gene product of which is predicted to be a sugar-binding, C-type lectin.
Journal ArticleDOI
Rfx6 directs islet formation and insulin production in mice and humans
Stuart Smith,Hui-Qi Qu,Nadine Taleb,Nina Kishimoto,David W. Scheel,Yang Lu,Ann-Marie Patch,Rosemary Grabs,Juehu Wang,Francis C. Lynn,Francis C. Lynn,Takeshi Miyatsuka,John J. Mitchell,Rina Seerke,Julie Désir,Serge Vanden Eijnden,Marc Abramowicz,Nadine Kacet,Jacques Weill,Marie Éve Renard,Mattia Gentile,Inger Hansen,Ken Dewar,Andrew T. Hattersley,Rennian Wang,Maria E. Wilson,Jeffrey D. Johnson,Constantin Polychronakos,Michael S. German +28 more
TL;DR: It is shown that the transcription factor Rfx6 directs islet cell differentiation downstream of Neurog3, a unique position for RFX6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans.
Journal ArticleDOI
PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population.
Quan Li,Hui-Qi Qu,Anne R. Rentfro,Megan L. Grove,Shaper Mirza,Yang Lu,Craig L. Hanis,Michael B. Fallon,Eric Boerwinkle,Susan P. Fisher-Hoch,Joseph B. McCormick +10 more
TL;DR: In this article, two single nucleotide polymorphisms (SNPs) in the PNPLA3 gene (i.e., rs738409 and rs2281135) were genotyped in 1532 individuals.
PNPLA3 Polymorphisms and Liver Aminotransferase Levels in a Mexican
Hui-Qi Qu,Anne R. Rento,Megan L. Groe,Shaper Mirza,Yang Lu,Craig L. Hanis,Michael B. Fallon,Eric Boerwinkle,Susan P. Fisher-Hoch,Joseph B. McCormick +9 more
TL;DR: A sex-specific association of PNPLA3 polymorphisms and elevated liver enzymes in a population-based study, independent of common pathological factors of the metabolic syndrome, suggests that sex hormones may mediate the sex effect.
Journal ArticleDOI
Genetic Control of Alternative Splicing in the TAP2 Gene: Possible Implication in the Genetics of Type 1 Diabetes
Hui-Qi Qu,Yang Lu,Luc Marchand,Francois Bacot,Rosalie Fréchette,Marie Catherine Tessier,Alexandre Montpetit,Constantin Polychronakos +7 more
TL;DR: In this paper, the authors show evidence of TAP2 association with type 1 diabetes that is independent of HLA DR-DQ and describe a plausible functional mechanism based on allele dependence of splicing into isoforms known to have differential peptide selectivities.