Stijn De Langhe

TL;DR: It is proposed that looking at the lung in general and branching in particular in terms of clocks may yield unexpected benefits, and efforts to parse the finer detail of lung bud signaling may need to be combined with broader consideration of overarching mechanisms that may be therapeutically easier to target.

TL;DR: The plasticity of hAFSC is illustrated to respond in different ways to different types of lung damage by expressing specific alveolar versus bronchiolar epithelial cell lineage markers, depending on the type of injury to recipient lung.

TL;DR: Current knowledge in the field is analyzed, gained from both basic and clinical research, to provide new insights into the disease process, and potential approaches to treatment of pulmonary fibrosis.

TL;DR: The “hard wiring” encoded within the genome that determines the emergence of the laryngotracheal groove and subsequently early lung branching morphogenesis is mediated by finely regulated, interactive growth factor signaling mechanisms that determine the automaticity of branching, interbranch length, stereotypy of branching), left-right asymmetry, and finally gas diffusion surface area.

TL;DR: PSMCs is identified as a stem cell niche for the variant Clara cells in the lung and paracrine Fgf10 signaling from the niche is critical for epithelial repair after naphthalene injury, which has implications for understanding the misregulation of lung repair in asthma and cancer.