R
Roy A. Frye
Researcher at Veterans Health Administration
Publications - 5
Citations - 5527
Roy A. Frye is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Histone deacetylase 2 & SIRT3. The author has an hindex of 5, co-authored 5 publications receiving 5111 citations.
Papers
More filters
Journal ArticleDOI
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Homayoun Vaziri,Scott K. Dessain,Scott K. Dessain,Elinor Ng Eaton,Shin-ichiro Imai,Roy A. Frye,Tej K. Pandita,Leonard Guarente,Robert A. Weinberg +8 more
TL;DR: It is proposed that hSir2, the human homolog of the S. cerevisiae Sir2 protein known to be involved in cell aging and in the response to DNA damage, binds and deacetylates the p53 protein with a specificity for its C-terminal Lys382 residue.
Journal ArticleDOI
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
Fan Yeung,Jamie E. Hoberg,Catherine S. Ramsey,Michael D Keller,David R. Jones,Roy A. Frye,Marty W. Mayo +6 more
TL;DR: It is demonstrated that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone deacetylase, regulates the transcriptional activity of NF‐κB and activity augments apoptosis in response to TNFα.
Journal ArticleDOI
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase
TL;DR: It is reported that mitochondria from mammalian cells contain intrinsic NAD-dependent deacetylase activity, which is inhibited by the NAD hydrolysis product nicotinamide, but not by trichostatin A, consistent with a class III de acetylase.
Book ChapterDOI
Measurement of mammalian histone deacetylase activity.
Journal ArticleDOI
Hepatic iron content and the risk of Staphylococcus aureus bacteremia in liver transplant recipients.
Nina Singh,Cheryl Wannstedt,Lois Keyes,Debra Mayher,Lisa Tickerhoof,Mohamed Akoad,Marilyn M. Wagener,Roy A. Frye,Thomas V. Cacciarelli +8 more
TL;DR: A readily quantifiable assessment of hepatic iron at the time of transplantation can potentially identify patients without carriage who may be at risk for early S aureus bacteremia.