R
Runsheng He
Researcher at Peking University
Publications - 5
Citations - 1296
Runsheng He is an academic researcher from Peking University. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 3, co-authored 4 publications receiving 890 citations.
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Journal ArticleDOI
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
Y Cao,Bin Su,Xianghua Guo,Wenjie Sun,Yong-Qiang Deng,Linlin Bao,Qinyu Zhu,Xu Zhang,Yinghui Zheng,Chenyang Geng,Xiaoran Chai,Runsheng He,Xiaofeng Li,Qi Lv,Hua Zhu,Wei Deng,Yanfeng Xu,Yanjun Wang,Luxin Qiao,Yafang Tan,Liyang Song,Guopeng Wang,Xiao-Xia Du,Ning Gao,Jiangning Liu,Junyu Xiao,Xiao-Dong Su,Zongmin Du,Yingmei Feng,Chuan Qin,Cheng-Feng Qin,Ronghua Jin,X. Sunney Xie +32 more
TL;DR: It is shown that human neutralizing antibodies could be efficiently discovered by high-throughput single B-cell sequencing in response to pandemic infectious diseases.
Journal ArticleDOI
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Shuo Du,Y Cao,Qinyu Zhu,Pin Yu,Feifei Qi,Guopeng Wang,Xiao-Xia Du,Linlin Bao,Wei Deng,Hua Zhu,Jiangning Liu,Jianhui Nie,Yinghui Zheng,Haoyu Liang,Ruixue Liu,Shuran Gong,Hua Xu,Ayijiang Yisimayi,Qi Lv,Bo Wang,Runsheng He,Yunlin Han,Wenjie Zhao,Yali Bai,Yajin Qu,Xiang Gao,Chenggong Ji,Qisheng Wang,Ning Gao,Weijin Huang,Youchun Wang,X. Sunney Xie,Xiao-Dong Su,Junyu Xiao,Chuan Qin +34 more
TL;DR: The results rationalized a new RBD epitope that leads to high neutralization potency and demonstrated BD-368-2’s therapeutic potential in treating COVID-19, a SARS-CoV-2 pseudovirus at pM level and rescues mutation-induced neutralization escapes.
Posted ContentDOI
Structures of potent and convergent neutralizing antibodies bound to the SARS-CoV-2 spike unveil a unique epitope responsible for exceptional potency
Shuo Du,Y Cao,Qinyu Zhu,Guopeng Wang,Xiao-Xia Du,Runsheng He,Hua Xu,Yinghui Zheng,Bo Wang,Yali Bai,Chenggong Ji,Ayijiang Yisimayi,Qisheng Wang,Ning Gao,Sunney Xie,Xiao-Dong Su,Junyu Xiao +16 more
TL;DR: The results rationalize a unique epitope that leads to exceptional neutralization potency, and provide guidance for NAb therapeutics and vaccine designs against SARS-CoV-2.
Journal ArticleDOI
H3K4 demethylase KDM5B regulates cancer cell identity and epigenetic plasticity
Runsheng He,Besa Xhabija,Lijin Gopi,Jiji Thomas And G Muraleedhara Kurup,Zhishan Xu,Zhe Liu,Benjamin L. Kidder +6 more
TL;DR: In this paper , KDM5B-centric epigenetic and transcriptional patterns that support cancer cell plasticity were defined, where depleted cancer cells exhibit altered epigenetic profiles resembling a more primitive cellular state.
Posted ContentDOI
Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus
Feng Tian,Fan Zhou,Fan Zhou,Xiang Li,Wenping Ma,Honggui Wu,Ming Yang,Alec R. Chapman,Alec R. Chapman,David F. Lee,Longzhi Tan,Longzhi Tan,Dong Xing,Dong Xing,Guangjun Yin,Ayjan Semayel,Jing Wang,Wang Jia,Wang Jia,Wenjie Sun,Runsheng He,Siwei Zhang,Zhi-Jie Cao,Lin Wei,Shen Lu,De-Chang Yang,Y. J. Mao,Yuan Gao,Kexuan Chen,Yu Zhang,Xixi Liu,Jun Yong,Liying Yan,Yanyi Huang,Jie Qiao,Fuchou Tang,Ge Gao,X. Sunney Xie +37 more
TL;DR: The Genomic Architecture of Cells in Tissues (GeACT), a comprehensive genomic data base that collectively address the above needs with the goal of understanding the functional genome in action, is reported.