William M. Gwinn

TL;DR: These findings are the first to demonstrate the significant contribution of cyclophilin-CD147 interactions to inflammatory responses and provide a potentially novel approach for reducing inflammation-mediated diseases.

TL;DR: It is proposed that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses, providing a novel mechanism whereby asthmatic lung inflammation may be reduced.

TL;DR: IL-1α,IL-12, IL-18, and GM-CSF are critical cytokines for the induction of systemic and mucosal CTL after nasal immunization, and these cytokines may serve as effective adjuvants for nasal vaccine delivery.

TL;DR: Analysis of how oxygen tension affects the thymus at the cellular and molecular level suggests that regulatory mechanisms exist to maintain thymic cellular hypoxia in vivo and that oxygen tension may regulate thymocyte survival both in vitro and in vivo.

TL;DR: Serum collected 24 h after passive transfer had LeTx-neutralizing activity when tested using a standard LeTx neutralization assay, but neutralization titers measured using this assay did not correlate with protection against LeTx challenge, prompting the suggestion that this LeTxneutralization assay may be a more biologically relevant Neutralization assay to predict the in vivo protective capacity of Letx- neutralizing antibodies.