D
David Leitenberg
Researcher at George Washington University
Publications - 21
Citations - 748
David Leitenberg is an academic researcher from George Washington University. The author has contributed to research in topics: T cell & ZAP70. The author has an hindex of 11, co-authored 21 publications receiving 699 citations. Previous affiliations of David Leitenberg include Children's National Medical Center & Washington University in St. Louis.
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Journal ArticleDOI
CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans.
Julie T. Nguyen,Douglas P. Evans,Marisa Galvan,Karen E. Pace,David Leitenberg,Thanhmy N. Bui,Linda G. Baum +6 more
TL;DR: It is determined that CD45 can positively and negatively regulate galectin-1-induced T cell death, depending on the glycosylation status of the cells, and oligosaccharide-mediated clustering of CD45 facilitated galECTin- 1-induced cell death.
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Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes.
TL;DR: Comparing signaling characteristics of 9 single-chain receptors consisting of the H-2K(b) extracellular and transmembrane domains and various combinations of T cell signal transduction domains shows that it is possible to link TCR, coreceptor, and costimulatory activities in a single functional entity using modular domains.
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Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention
William M. Gwinn,Jesse M. Damsker,Rustom Falahati,Ifeanyi Okwumabua,Ann E. Kelly-Welch,Achsah D. Keegan,Christophe Vanpouille,James J. Lee,Lindsay A. Dent,David Leitenberg,Michael Bukrinsky,Stephanie L. Constant +11 more
TL;DR: It is proposed that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses, providing a novel mechanism whereby asthmatic lung inflammation may be reduced.
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A Secreted Protein from the Human Hookworm Necator americanus Binds Selectively to NK Cells and Induces IFN-γ Production
George C.-F. Hsieh,Alex Loukas,Allison M. Wahl,Monica Bhatia,Yan Wang,Angela L. Williamson,Kylene W. Kehn,Haruhiko Maruyama,Peter J. Hotez,David Leitenberg,Jeffrey M. Bethony,Stephanie L. Constant +11 more
TL;DR: This work found that a protein(s) from ES products of adult N. americanus bound selectively to mouse and human NK cells, and this is the first report of a pathogen protein that binds exclusively to NK cells and the first reported of a nematode-derived product that induces abundant levels of cytokines from NK cells.
Journal Article
The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.
TL;DR: The results show that the zeta-chain ITAMs, in the absence of the gamma, delta, and epsilon ITams, are sufficient for the activation and functional maturation of primary T lymphocytes, and supports the isolated use of the zetas in the development of surrogate TCRs for therapeutic purposes.