Ryan Duggan

TL;DR: It is found that spontaneous CD8(+) T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytosolic DNA sensing pathway.

TL;DR: A simplified and quantitative flow cytometry based method to measure IR-induced gammaH2AX in cells is developed and demonstrated strong correlation to values obtained by a standard automated digital microscopic foci analysis along with NIH ImageJ custom macro software.

TL;DR: It is demonstrated in mouse syngeneic tumor models that venetoclax can augment the anti-tumor efficacy of ICIs accompanied by the increase of PD-1+ T effector memory cells, and it is demonstrated that theAnti-apoptotic family member BCL-XL provides a survival advantage in effector T cells following inhibition of B CL-2.

TL;DR: This is the first study reporting a predictive association between plasma biomarkers and subsequent cerebral cavernous malformation disease clinical activity, and may be applied in clinical prognostication and stratification of cases in clinical trials.

TL;DR: Evaluated CTC interrogation with respect to the AR found increased AR expression and nuclear localization are associated with elevated co-expression of Ki-67, consistent with the continued role for AR in castration-resistant disease.