Seng Ryong Woo

TL;DR: It is found that spontaneous CD8(+) T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytosolic DNA sensing pathway.

TL;DR: The generation of antitumor CD8+ T cell responses requires type I interferon responsiveness in host antigen-presenting cells and the response is dominated by T-cells that secrete polypeptide A into the T cells of the immune system.

TL;DR: The characteristics of T cell-inflamed versus non-Inflamed tumors, including a type I interferon (IFN) signature associated with T cell priming against tumor antigens, are discussed.

TL;DR: The data suggest that in vitroactivation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1–dependent cell death.

TL;DR: A subset of patients with a variety of cancers shows evidence of a natural adaptive immune response against their tumor, as evidenced by spontaneous T-cell infiltration, circulating anti-tumor T cells, or antibody responses, which raise a new critical fundamental question—what innate immune signals might be generated in the context of non-pathogen-induced cancers that drive productive antigen presentation toward induction of an adaptiveimmune response.