Ryan T. Davis

TL;DR: Recent advances in single-cell technologies are reviewed and discussed in detail how they can be leveraged to understand tumour heterogeneity and metastasis.

TL;DR: A comprehensive cell atlas provides insights into the cellular blueprint of the human breast epithelium and will form the foundation to understand how the system goes awry during breast cancer.

TL;DR: Heterogeneous and distinct transcriptome programs in breast cancer micrometastasis associated with upregulated mitochondrial oxidative phosphorylation are demonstrated.

TL;DR: The vascularized micro-tumor (VMT) as mentioned in this paper is a three-dimensional model system that recapitulates the complex human tumor microenvironment, including perfused vasculature, within a transparent microfluidic device, allowing real-time study of drug responses and tumor-stromal interactions.

TL;DR: This work attempts to integrate all the known mechanisms for APA regulation into a unified model, which not only explains most of previous results, but also provides testable predictions that will improve the understanding of the mechanistic details of APAregulation.