M
Mei Kong
Researcher at Zhejiang University
Publications - 47
Citations - 4488
Mei Kong is an academic researcher from Zhejiang University. The author has contributed to research in topics: Glutamine & Cancer. The author has an hindex of 22, co-authored 41 publications receiving 3636 citations. Previous affiliations of Mei Kong include Beckman Research Institute & City of Hope National Medical Center.
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Journal ArticleDOI
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Julian J. Lum,Daniel E. Bauer,Mei Kong,Marian H. Harris,Chi Li,Tullia Lindsten,Craig B. Thompson +6 more
TL;DR: Using growth factor-dependent cells from Bax/Bak-deficient mice, it is demonstrated that apoptosis is not essential to limit cell autonomous survival and growth factor signal transduction is required to direct the utilization of sufficient exogenous nutrients to maintain cell viability.
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Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
Miranda Y. Fong,Weiying Zhou,Liang Liu,Aileen Y. Alontaga,Manasa Chandra,Jonathan Ashby,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Shasha Li,Andrew R. Chin,George Somlo,Melanie R. Palomares,Zhuo Li,Jacob R. Tremblay,Akihiro Tsuyada,Guoqiang Sun,Michael A. Reid,Xiwei Wu,Piotr Swiderski,Xiubao Ren,Yanhong Shi,Mei Kong,Wenwan Zhong,Yuan Chen,Shizhen Emily Wang +24 more
TL;DR: It is demonstrated that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
Min Pan,Michael A. Reid,Xazmin H. Lowman,Rajan P. Kulkarni,Rajan P. Kulkarni,Thai Q. Tran,Xiaojing Liu,Ying Yang,Jenny E. Hernandez-Davies,Kimberly K. Rosales,Haiqing Li,Willy Hugo,Chunying Song,Xiangdong Xu,Dustin E. Schones,David K. Ann,Viviana Gradinaru,Roger S. Lo,Jason W. Locasale,Mei Kong +19 more
TL;DR: It is shown that the core region of solid tumours displayed glutamine deficiency compared with other amino acids, which led to dramatic histone hypermethylation due to decreased α-ketoglutarate levels, a key cofactor for the Jumonji-domain-containing histone demethylases.
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Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation
Joshua J. Gruber,D. Steven Zatechka,Leah R. Sabin,Jeongsik Yong,Julian J. Lum,Mei Kong,Wei-Xing Zong,Zhenxi Zhang,Chi Kong Lau,Jason S. Rawlings,Sara Cherry,James N. Ihle,Gideon Dreyfuss,Craig B. Thompson +13 more
TL;DR: Evidence is provided for a role for Ars2 in RNA interference regulation during cell proliferation and reduced the levels of several miRNAs, including miR-21, let-7, andMiR-155, that are implicated in cellular transformation.
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α4 Is an Essential Regulator of PP2A Phosphatase Activity
TL;DR: It is demonstrated that overexpression of alpha4 protects cells from a variety of stress stimuli, including DNA damage and nutrient limitation, and plays a required role in regulating the assembly and maintenance of adaptive PP2A phosphatase complexes.