R
Ryohei Otani
Researcher at Dokkyo Medical University
Publications - 27
Citations - 449
Ryohei Otani is an academic researcher from Dokkyo Medical University. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 8, co-authored 24 publications receiving 313 citations. Previous affiliations of Ryohei Otani include Fujita Health University & University of Tokyo.
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Journal ArticleDOI
A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
Hideyuki Arita,Hideyuki Arita,Kai Yamasaki,Yuko Matsushita,Taishi Nakamura,Taishi Nakamura,Asanao Shimokawa,Hirokazu Takami,Hirokazu Takami,Shota Tanaka,Akitake Mukasa,Mitsuaki Shirahata,Saki Shimizu,Kaori Suzuki,Kuniaki Saito,Keiichi Kobayashi,Fumi Higuchi,Takeo Uzuka,Ryohei Otani,Kaoru Tamura,Kazutaka Sumita,Makoto Ohno,Yasuji Miyakita,Naoki Kagawa,Naoya Hashimoto,Ryusuke Hatae,Koji Yoshimoto,Naoki Shinojima,Hideo Nakamura,Yonehiro Kanemura,Yoshiko Okita,Manabu Kinoshita,Kenichi Ishibashi,Tomoko Shofuda,Yoshinori Kodama,Kanji Mori,Yusuke Tomogane,Junya Fukai,Koji Fujita,Yuzo Terakawa,Naohiro Tsuyuguchi,Shusuke Moriuchi,Masahiro Nonaka,Hiroyoshi Suzuki,Makoto Shibuya,Taketoshi Maehara,Nobuhito Saito,Motoo Nagane,Nobutaka Kawahara,Keisuke Ueki,Toshiki Yoshimine,Etsuo Miyaoka,Ryo Nishikawa,Takashi Komori,Yoshitaka Narita,Koichi Ichimura +55 more
TL;DR: The findings suggest that a combination of IDH, TERT, and MGMT refines the classification of grade II-IV diffuse gliomas, and patients with TERT mutant-MGMT unmethylated GBM have the poorest prognosis.
Journal ArticleDOI
Genetic and epigenetic stability of oligodendrogliomas at recurrence
Koki Aihara,Akitake Mukasa,Genta Nagae,Masashi Nomura,Shogo Yamamoto,Hiroki R. Ueda,Kenji Tatsuno,Junji Shibahara,Miwako Takahashi,Toshimitsu Momose,Shota Tanaka,Shunsaku Takayanagi,Shunsuke Yanagisawa,Takahide Nejo,Satoshi Takahashi,Mayu Omata,Ryohei Otani,Kuniaki Saito,Yoshitaka Narita,Motoo Nagane,Ryo Nishikawa,Keisuke Ueki,Hiroyuki Aburatani,Nobuhito Saito +23 more
TL;DR: Although oligodendroglioma displays marked mutational heterogeneity, histological malignant transformation accompanying events such as considerable increase in mutation number and epigenetic profile change were not observed at recurrence, indicating that noticeable temporal and spatial genetic heterogeneity in oligodendedrogliomas does not result in rapid tumor progression.
Journal ArticleDOI
Distinct molecular profile of diffuse cerebellar gliomas.
Masashi Nomura,Akitake Mukasa,Genta Nagae,Shogo Yamamoto,Kenji Tatsuno,Hiroki R. Ueda,Shiro Fukuda,Takayoshi Umeda,Tomonari Suzuki,Ryohei Otani,Keiichi Kobayashi,Takashi Maruyama,Shota Tanaka,Shunsaku Takayanagi,Takahide Nejo,Satoshi Takahashi,Koichi Ichimura,Taishi Nakamura,Yoshihiro Muragaki,Yoshitaka Narita,Motoo Nagane,Keisuke Ueki,Ryo Nishikawa,Junji Shibahara,Hiroyuki Aburatani,Nobuhito Saito +25 more
TL;DR: DNA methylation profile analysis demonstrated that all DCGs except for those with H3F3A mutations were categorized in the “RTK I (PDGFRA)” group, and those DCGs had a gene expression signature that was highly associated with PDGFRA, and promoter methylation of transcription factors genes associated with glial development showed a characteristic pattern presumably reflecting their tumor origin.
Journal ArticleDOI
Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma
Ryohei Otani,Ryohei Otani,Akitake Mukasa,Masahiro Shin,Mayu Omata,Shunsaku Takayanagi,Shota Tanaka,Keisuke Ueki,Nobuhito Saito +8 more
TL;DR: Activation of the PI3K/Akt pathway and Brachyury copy number gain are strongly associated with Brachyuries overexpression, which appears to be a key event in chordoma growth regulation.
Journal ArticleDOI
DNA demethylation is associated with malignant progression of lower-grade gliomas.
Masashi Nomura,Kuniaki Saito,Kuniaki Saito,Koki Aihara,Genta Nagae,Shogo Yamamoto,Kenji Tatsuno,Hiroki Ueda,Shiro Fukuda,Takayoshi Umeda,Shota Tanaka,Shunsaku Takayanagi,Ryohei Otani,Takahide Nejo,Taijun Hana,Satoshi Takahashi,Yosuke Kitagawa,Mayu Omata,Fumi Higuchi,Taishi Nakamura,Yoshihiro Muragaki,Yoshitaka Narita,Motoo Nagane,Ryo Nishikawa,Keisuke Ueki,Nobuhito Saito,Hiroyuki Aburatani,Akitake Mukasa,Akitake Mukasa +28 more
TL;DR: The authors' data indicated that demethylation of the G-CIMP profile found in a subset of recurrent gliomas reflects accelerated cell divisions accompanied by malignant transformation.