S
Sabine Vettorazzi
Researcher at University of Ulm
Publications - 32
Citations - 736
Sabine Vettorazzi is an academic researcher from University of Ulm. The author has contributed to research in topics: Inflammation & Glucocorticoid receptor. The author has an hindex of 12, co-authored 26 publications receiving 479 citations. Previous affiliations of Sabine Vettorazzi include Leibniz Association.
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Journal ArticleDOI
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
Sabine Vettorazzi,Sabine Vettorazzi,Constantin Bode,Lien Dejager,Lucien Frappart,Ekaterina Shelest,Carina Klaßen,Alpaslan Tasdogan,Holger M. Reichardt,Claude Libert,Marion Schneider,Falk Weih,N. Henriette Uhlenhaut,Jean-Pierre David,Markus H. Gräler,Anna Kleiman,Jan Tuckermann,Jan Tuckermann +17 more
TL;DR: Findings support a critical role for SphK1 induction in the suppression of lung inflammation by glucocorticoids, and therefore provide rationales for effective anti-inflammatory therapies.
Journal ArticleDOI
Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor.
Laura Escoter-Torres,Giorgio Caratti,Aikaterini Mechtidou,Jan Tuckermann,Nina Henriette Uhlenhaut,Sabine Vettorazzi +5 more
TL;DR: This review focusses on newly identified target genes and GR co-regulators that are important for its anti-inflammatory effects in innate immune cells, as well as mutations within the GR itself that shed light on its transcriptional activity.
Journal ArticleDOI
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity
Carmelo Quarta,Christoffer Clemmensen,Zhimeng Zhu,Bin Yang,Sini S. Joseph,Dominik Lutter,Chun-Xia Yi,Elisabeth Graf,Cristina García-Cáceres,Beata Legutko,Katrin Fischer,Robert Brommage,Philippe Zizzari,Philippe Zizzari,Bernardo S. Franklin,Bernardo S. Franklin,Bernardo S. Franklin,Martin Krueger,Marco Koch,Sabine Vettorazzi,Pengyun Li,Susanna M. Hofmann,Mostafa Bakhti,Aimée Bastidas-Ponce,Heiko Lickert,Tim M. Strom,Valerie Gailus-Durner,Ingo Bechmann,Diego Perez-Tilve,Jan Tuckermann,Martin Hrabě de Angelis,Darleen A. Sandoval,Daniela Cota,Daniela Cota,Eicke Latz,Eicke Latz,Eicke Latz,Randy J. Seeley,Timo D. Müller,Richard D. DiMarchi,Brian Finan,Matthias H. Tschöp +41 more
TL;DR: A GLP-1-directed glucocorticoid pharmacology represents a safe and efficacious therapy option for diet-induced immunometabolic derangements and the resulting obesity by reversing hypothalamic and systemic inflammation while improving glucose tolerance and insulin sensitivity.
Journal ArticleDOI
Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition.
Kristina M. Mueller,Kerstin Hartmann,Doris Kaltenecker,Sabine Vettorazzi,Mandy Bauer,Lea Mauser,Sabine Amann,Sigrid Jall,Katrin Fischer,Harald Esterbauer,Timo D. Müller,Matthias H. Tschöp,Christoph Magnes,Johannes Haybaeck,Thomas Scherer,Natalie Bordag,Jan Tuckermann,Richard Moriggl,Richard Moriggl +18 more
TL;DR: The adipocyte GR is indispensable for the feeding-fasting transition but also promotes adiposity and associated metabolic disorders in fat-fed and aged mice, and exerts central but diverging roles in the regulation of metabolic homeostasis depending on the energetic state.
Journal ArticleDOI
Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver
Adrija Kalvisa,Majken S. Siersbæk,Stine M. Præstholm,Line Julie Lindorf Christensen,Ronni Nielsen,Oliver Stöhr,Sabine Vettorazzi,Jan Tuckermann,Morris F. White,Susanne Mandrup,Lars Grøntved +10 more
TL;DR: The feeding response was disrupted in diet-induced obese animals, which was associated with dysregulation of several corticosteroid- and insulin-regulated genes, providing mechanistic insights to dysregulated circadian gene transcription associated with obesity.