S
Sacha B. Nelson
Researcher at Brandeis University
Publications - 140
Citations - 30371
Sacha B. Nelson is an academic researcher from Brandeis University. The author has contributed to research in topics: Visual cortex & Excitatory postsynaptic potential. The author has an hindex of 68, co-authored 134 publications receiving 27897 citations. Previous affiliations of Sacha B. Nelson include Salk Institute for Biological Studies & Center for Neural Science.
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Homeostatic plasticity in the developing nervous system
TL;DR: Evidence is discussed from a number of systems that homeostatic synaptic plasticity is crucial for processes ranging from memory storage to activity-dependent development, and how these processes maintain stable activity states in the face of destabilizing forces is discussed.
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Activity-dependent scaling of quantal amplitude in neocortical neurons
TL;DR: A new form of synaptic plasticity is described that increases or decreases the strength of all of a neuron's synaptic inputs as a function of activity, and may help to ensure that firing rates do not become saturated during developmental changes in the number and strength of synaptic inputs.
Journal ArticleDOI
Synaptic plasticity: taming the beast
L. F. Abbott,Sacha B. Nelson +1 more
TL;DR: This work reviews three Hebbian forms of plasticity—synaptic scaling, spike-timing dependent plasticity and synaptic redistribution—and discusses their functional implications.
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Synaptic depression and cortical gain control
TL;DR: Modeling work based on experimental measurements indicates that short-term depression of intracortical synapses provides a dynamic gain-control mechanism that allows equal percentage rate changes on rapidly and slowly firing afferents to produce equal postsynaptic responses.
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A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex
Hiroki Taniguchi,Miao He,Priscilla Wu,Sangyong Kim,Raehum Paik,Ken Sugino,Duda Kvitsani,Yu Fu,Jiangteng Lu,Ying Lin,Goichi Miyoshi,Yasuyuki Shima,Gord Fishell,Sacha B. Nelson,Z. Josh Huang +14 more
TL;DR: Using genetic engineering in mice, approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons are generated, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior.