Hiroki Taniguchi

TL;DR: Using genetic engineering in mice, approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons are generated, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior.

TL;DR: It is shown that, in contrast to pyramidal cells, the response of somatostatin-expressing inhibitory neurons in the superficial layers of the mouse visual cortex increases with stimulation of the receptive-field surround, establishing a cortical circuit for surround suppression and attributing a particular function to a genetically defined type of inhibitory neuron.

TL;DR: In this article, an optogenetic activation of parvalbumin-positive (PV+) interneurons in the mouse primary visual cortex (V1) sharpens neuronal feature selectivity and improves perceptual discrimination.

TL;DR: This work combines rabies-virus-dependent retrograde mono-trans-synaptic labelling with genetics to control the location, number and type of ‘starter’ cortical neurons, from which they trace their presynaptic neurons.

TL;DR: It is shown that optogenetic activation of parvalbumin-positive (PV+) interneurons in the mouse primary visual cortex (V1) sharpens neuronal feature selectivity and improves perceptual discrimination, the first demonstration that visual coding and perception can be improved by increased spiking of a specific subtype of cortical inhibitory interneuron.