S
Sachiko Akashi-Takamura
Researcher at Aichi Medical University
Publications - 43
Citations - 3991
Sachiko Akashi-Takamura is an academic researcher from Aichi Medical University. The author has contributed to research in topics: TLR4 & Receptor. The author has an hindex of 25, co-authored 41 publications receiving 3452 citations. Previous affiliations of Sachiko Akashi-Takamura include University of Tokyo.
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Journal ArticleDOI
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
Nobuhiko Kayagaki,Michael Wong,Irma B. Stowe,Sree R. Ramani,Lino C. Gonzalez,Sachiko Akashi-Takamura,Kensuke Miyake,Juan Zhang,Wyne P. Lee,Artur Muszyński,Lennart S. Forsberg,Russell W. Carlson,Vishva M. Dixit +12 more
TL;DR: It is shown that macrophages loaded with synthetic lipid A, E. coli lipopolysaccharide (LPS), or S. typhimurium LPS activate caspase-11 independently of the LPS receptor Toll-like receptor 4 (TLR4), revealing a TLR4-independent mechanism for innate immune recognition of LPS.
Journal ArticleDOI
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase
Sachie Hiratsuka,Akira Watanabe,Yoshiko Sakurai,Sachiko Akashi-Takamura,Sachie Ishibashi,Kensuke Miyake,Masabumi Shibuya,Shizuo Akira,Hiroyuki Aburatani,Yoshiro Maru +9 more
TL;DR: It is shown that serum amyloid A (SAA) 3, which is induced in pre-metastatic lungs by S 100A8 and S100A9, has a role in the accumulation of myeloid cells and acts as a positive-feedback regulator for chemoattractant secretion.
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Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.
TL;DR: It is shown that TRAM recruits TRIF to the plasma membrane and the internalized signaling complex consisting of TLR4 and TRAM colocalizes with TRAF3, a signaling molecule downstream of TRIF, in endosome/lysosome after relocation from the cell surface.
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TLR accessory molecules.
TL;DR: It is important to understand how TLR signaling is controlled by these accessory molecules, which could be promising targets for therapeutic intervention in infectious disease and immune disorders.
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A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
Koichiro Takahashi,Takuma Shibata,Sachiko Akashi-Takamura,Takashi Kiyokawa,Yasutaka Wakabayashi,Natsuko Tanimura,Toshihiko Kobayashi,Fumi Matsumoto,Ryutaro Fukui,Taku Kouro,Yoshinori Nagai,Kiyoshi Takatsu,Shin-ichiroh Saitoh,Kensuke Miyake +13 more
TL;DR: The results suggest that PRAT4A regulates the subcellular distribution and response of multiple TLRs and is required for both innate and adaptive immune responses.