S
Sachin Mulik
Researcher at Boston Children's Hospital
Publications - 34
Citations - 1269
Sachin Mulik is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Cytotoxic T cell & Corneal neovascularization. The author has an hindex of 16, co-authored 30 publications receiving 996 citations. Previous affiliations of Sachin Mulik include Harvard University & University of Texas Health Science Center at Tyler.
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Journal ArticleDOI
Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes
Michael Walch,Farokh Dotiwala,Sachin Mulik,Jerome Thiery,Tomas Kirchhausen,Carol Clayberger,Alan M. Krensky,Denis Martinvalet,Judy Lieberman +8 more
TL;DR: Mice expressing transgenic granulysin are better able to clear Listeria monocytogenes and play an unexpected role in bacterial defense, suggesting that granzymes disrupt multiple vital bacterial pathways.
Journal ArticleDOI
Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites
Farokh Dotiwala,Sachin Mulik,Sachin Mulik,Rafael B. Polidoro,Rafael B. Polidoro,Rafael B. Polidoro,James Ansara,Barbara A. Burleigh,Michael Walch,Ricardo T. Gazzinelli,Judy Lieberman,Judy Lieberman +11 more
TL;DR: GNLY-transgenic mice are protected against infection by T. cruzi and T. gondii, and survive infections that are lethal to wild-type mice, and GNLY, PFN- and Gzm-mediated elimination of intracellular protozoan parasites is an unappreciated immune defense mechanism.
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Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1
Naveen K. Rajasagi,Pradeep B. J. Reddy,Amol Suryawanshi,Sachin Mulik,Per Gjorstrup,Barry T. Rouse +5 more
TL;DR: These findings are, to the authors' knowledge, the first to show that RvE1 treatment could represent a novel approach to control lesion severity in a virally induced immunopathological disease.
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Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts
Ângela C. Crespo,Ângela C. Crespo,Ângela C. Crespo,Sachin Mulik,Farokh Dotiwala,James Ansara,Sumit Sen Santara,Kayleigh Ingersoll,Cristian Ovies,Caroline Junqueira,Caroline Junqueira,Tamara Tilburgs,Jack L. Strominger,Judy Lieberman +13 more
TL;DR: It is shown that human dNK cells highly express the antimicrobial peptide granulysin (GNLY) and selectively transfer it via nanotubes to extravillous trophoblasts to kill intracellular Listeria monocytogenes (Lm) without killing the trophoblast.
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Role of miR-132 in Angiogenesis after Ocular Infection with Herpes Simplex Virus
Sachin Mulik,John Xu,Pradeep B. J. Reddy,Naveen K. Rajasagi,Fernanda Gimenez,Shalini Sharma,Patrick Y. Lu,Barry T. Rouse +7 more
TL;DR: This study shows that miR-132 expression was up-regulated after ocular infection with HSV, an event that involved the production of both VEGF-A and IL-17, and holds promise as a therapeutic approach to control an ocular lesion that is an important cause of human blindness.