Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts
Ângela C. Crespo,Ângela C. Crespo,Ângela C. Crespo,Sachin Mulik,Farokh Dotiwala,James Ansara,Sumit Sen Santara,Kayleigh Ingersoll,Cristian Ovies,Caroline Junqueira,Caroline Junqueira,Tamara Tilburgs,Jack L. Strominger,Judy Lieberman +13 more
TLDR
It is shown that human dNK cells highly express the antimicrobial peptide granulysin (GNLY) and selectively transfer it via nanotubes to extravillous trophoblasts to kill intracellular Listeria monocytogenes (Lm) without killing the trophoblast.About:
This article is published in Cell.The article was published on 2020-09-03 and is currently open access. It has received 103 citations till now. The article focuses on the topics: GNLY & Granulysin.read more
Citations
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Infections at the maternal-fetal interface: an overview of pathogenesis and defence.
Christina Megli,Carolyn B. Coyne +1 more
TL;DR: In this article, Megli et al. discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission, and provide an overview of how various viral, bacterial and parasitic pathogens traverse the maternal-fetal interface and cause disease.
Journal ArticleDOI
Single-cell Immune Landscape of Human Recurrent Miscarriage
Feiyang Wang,Wentong Jia,Mengjie Fan,Xuan Shao,Zhilang Li,Yongjie Liu,Yeling Ma,Yu-xia Li,Rong Li,Qiang Tu,Yan-Ling Wang +10 more
TL;DR: In this article, the cellular and molecular signatures of decidual and peripheral leukocytes in normal and unexplained recurrent miscarriage (RM) pregnancies at the early stage of gestation were analyzed using single-cell RNA-sequencing.
Journal ArticleDOI
Tunneling nanotubes: Reshaping connectivity
TL;DR: Tunneling nanotubes (TNTs) represent a direct way of communication between distant cells for the diffusion of various cellular material, including survival or death signals, genetic material, organelles, and pathogens as discussed by the authors.
Journal ArticleDOI
Role of Decidual Natural Killer Cells in Human Pregnancy and Related Pregnancy Complications.
Xiuhong Zhang,Haiming Wei +1 more
TL;DR: The role of decidual natural killer (dNK) cells in normal pregnancy and pathological pregnancy, including preeclampsia, recurrent spontaneous abortion, endometriosis, and recurrent implantation failure, is discussed in this paper.
Journal ArticleDOI
How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy
Oisin Huhn,Oisin Huhn,Xiaohui Zhao,Laura Esposito,Ashley Moffett,Francesco Colucci,Francesco Colucci,Andrew M. Sharkey +7 more
TL;DR: Innate lymphoid cells (ILC) are the most abundant immune cells in the uterine mucosa both before and during pregnancy and they play important roles in regulating placental development but exactly how they contribute to the successful outcome of pregnancy is still unclear.
References
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Siglecs and their roles in the immune system
TL;DR: The postulated functions of the recently discovered CD33-related Siglecs are discussed and the factors that seem to be driving their rapid evolution are considered.
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Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Jacob H. Hanna,Debra Goldman-Wohl,Yaron Hamani,Inbal Avraham,Caryn Greenfield,Shira Natanson-Yaron,Diana Prus,Leonor Cohen-Daniel,Tal I. Arnon,Irit Manaster,Roi Gazit,Vladimir Yutkin,Daniel Benharroch,Angel Porgador,Eli Keshet,Simcha Yagel,Ofer Mandelboim +16 more
TL;DR: It is shown that dNK cells, but not peripheral blood–derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein–10 chemokines.
Journal ArticleDOI
Natural killer cells and pregnancy.
TL;DR: No convincing evidence of uterine maternal T-cell recognition of placental trophoblast cells has been found, but instead, there might be maternal allorecognition mediated by uterine natural killer cells that recognize unusual fetal trophOBlast MHC ligands.
Journal ArticleDOI
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.
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