Sahadevan Raman

TL;DR: The first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq are taken and system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration is combined.

TL;DR: It is determined that a M. tuberculosis sigH mutant is more susceptible to oxidative stresses and that the inducible expression of the thioredoxin reductase/thiOREDoxin genes trxB2/trxC and a gene of unknown function is regulated by sigH via expression from promoters directly recognized by SigH.

TL;DR: It is found that the expression of sigD is stable throughout log phase and stationary phase but that it declines rapidly with oxygen depletion, and the in vivo promoters of these genes are identified, determined to be a consensus promoter sequence that is putatively recognized by SigD.

TL;DR: Mycobacterium tuberculosis sigL encodes an extracytoplasmic function (ECF) sigma factor and is adjacent to a gene for a membrane protein (RV0736) that contains a conserved HXXXCXXC sequence, suggesting that Rv0736 may encode an anti-sigma factor of SigL.

TL;DR: A comparative analysis of protein evolution highlights gene families that are associated with the adaptation of environmental Mycobacteria to obligate pathogenesis, including fatty acid metabolism, DNA repair, and molybdopterin biosynthesis and reinforces recent findings suggesting that small noncoding RNAs are more common in Myc Cobacteria than previously expected.