B
Brian Weiner
Researcher at Broad Institute
Publications - 32
Citations - 2505
Brian Weiner is an academic researcher from Broad Institute. The author has contributed to research in topics: Geminal & Propagator. The author has an hindex of 18, co-authored 31 publications receiving 2327 citations. Previous affiliations of Brian Weiner include University of Massachusetts Medical School & Florida Atlantic University.
Papers
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Journal ArticleDOI
Tuberculosis drug resistance mutation database.
Andreas Sandgren,Michael J. Strong,Preetika Muthukrishnan,Brian Weiner,George M. Church,Megan Murray +5 more
TL;DR: Sandgren et al. as mentioned in this paper described a new comprehensive resource on drug resistance mutations in M. tuberculosis, which they used to study drug-resistant mutations in drug-free tuberculosis.
Journal ArticleDOI
The Mycobacterium tuberculosis regulatory network and hypoxia.
James E. Galagan,Kyle J. Minch,Matthew W. Peterson,Anna Lyubetskaya,Elham Azizi,Linsday Sweet,Antonio L.C. Gomes,Tige R. Rustad,Gregory Dolganov,Irina Glotova,Thomas Abeel,Thomas Abeel,Chris Mahwinney,Adam D. Kennedy,Rene Allard,William Brabant,Andrew S Krueger,Suma Jaini,Brent Honda,Wen-Han Yu,Mark J. Hickey,Jeremy Zucker,Christopher D. Garay,Brian Weiner,Peter Sisk,Christian Stolte,Jessica K. Winkler,Yves Van de Peer,Paul Iazzetti,Diogo M. Camacho,Jonathan M. Dreyfuss,Yang Liu,Anca Dorhoi,Hans-Joachim Mollenkopf,Paul Drogaris,Julie Lamontagne,Yiyong Zhou,Julie Piquenot,Sang Tae Park,Sahadevan Raman,Stefan H. E. Kaufmann,Robert P. Mohney,Daniel Chelsky,D. Branch Moody,David R. Sherman,David R. Sherman,Gary K. Schoolnik +46 more
TL;DR: The first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq are taken and system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration is combined.
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Interpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid production.
Caroline Colijn,Caroline Colijn,Caroline Colijn,Aaron Brandes,Jeremy Zucker,Desmond S. Lun,Desmond S. Lun,Brian Weiner,Maha R. Farhat,Tan-Yun Cheng,D. Branch Moody,Megan Murray,James E. Galagan,James E. Galagan +13 more
TL;DR: E-Flux as mentioned in this paper extends the technique of Flux Balance Analysis by modeling maximum flux constraints as a function of measured gene expression, which can predict changes in metabolic flux capacity.
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TB database: an integrated platform for tuberculosis research
T. B. K. Reddy,Robert Riley,Farrell Wymore,Phillip Montgomery,David DeCaprio,Reinhard Engels,Marcel Gellesch,Jeremy Hubble,Dennis Jen,Heng Jin,Michael Koehrsen,Lisa Larson,Maria Mao,Michael Nitzberg,Peter Sisk,Christian Stolte,Brian Weiner,Jared White,Zachariah K. Zachariah,Gavin Sherlock,James E. Galagan,Catherine A. Ball,Gary K. Schoolnik +22 more
TL;DR: The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers, and provides a unique discovery platform for TB research.
Journal ArticleDOI
HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes
Mohammad Q. Hassan,Rahul S. Tare,Suk Hee Lee,Matthew Mandeville,Brian Weiner,Martin Montecino,Andre J. Van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +9 more
TL;DR: It is proposed that HOXA10 activates RUNX2 in mesenchymal cells, contributing to the onset of osteogenesis, and that HOxA10 subsequently supports bone formation by direct regulation of osteoblast phenotypic genes.