S
Sai-Juan Chen
Researcher at Ruijin Hospital
Publications - 33
Citations - 2943
Sai-Juan Chen is an academic researcher from Ruijin Hospital. The author has contributed to research in topics: Acute promyelocytic leukemia & Arsenic trioxide. The author has an hindex of 17, co-authored 33 publications receiving 2837 citations. Previous affiliations of Sai-Juan Chen include Harbin Medical University.
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Journal ArticleDOI
Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients
Zhi-Xiang Shen,Guo-Qiang Chen,Jian-Hua Ni,Xiu-Shong Li,Shu-Min Xiong,Qian-Yao Qiu,Jun Zhu,Wei Tang,Guan-Lin Sun,Kan-Qi Yang,Yu Chen,Li Zhou,Zhi-Wen Fang,Yan-Ting Wang,Jun Ma,Peng Zhang,Ting-Dong Zhang,Sai-Juan Chen,Zhu Chen,Zhen-Yi Wang +19 more
TL;DR: As2O3 treatment is an effective and relatively safe drug in APL patients refractory to ATRA and conventional chemotherapy, and Pharmacokinetic studies showed that after a peak level of 5.54 micromol/L, plasma arsenic was rapidly eliminated, and the continuous administration of As2O2 did not alter its pharmacokinetic behaviors.
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Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia.
Xun Cai,Y. Shen,Qi Zhu,Peimin Jia,Yun Yu,L Zhou,Y Huang,Jiwang Zhang,S M Xiong,Sai-Juan Chen,Zhen-yi Wang,Zhu Chen,Guo-Qiang Chen +12 more
TL;DR: The results encouraged us to hypothesize that As2O3 induces APL cell differentiation through direct or indirect activation of retinoic acid receptor-related signaling pathway(s), while ΔΨm collapse is the common mechanism of As 2O3-induced apoptosis.
Journal ArticleDOI
Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
Sai-Juan Chen,Arthur Zelent,Jian-Hua Tong,Huai Qin Yu,Zhen Yi Wang,Josette Derré,Roland Berger,Samuel Waxman,Zhu Chen +8 more
TL;DR: Molecular studies showed rearrangements of the retinoic acid receptor alpha (RAR alpha) gene but no rearrangement of the promyelocytic leukemia gene consistent with the cytogenetic data.
Journal ArticleDOI
Arsenic trioxide, a therapeutic agent for APL.
TL;DR: Interestingly, As2O3 over a wide range of concentration induces degradation of a key leukemogenic protein, PML–RARα, as well as the wild-type PML, thus setting up a good example of targeting therapy for human cancers.
Journal ArticleDOI
Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage.
Y. Shen,Shen Zx,H Yan,Chen J,Zeng Xy,Jun-Min Li,Li Xs,Wen Wu,Shu-Min Xiong,Wei-Li Zhao,Tang W,Wu F,Liu Yf,C Niu,Zhen-yi Wang,Sai-Juan Chen,Zhu Chen +16 more
TL;DR: It is demonstrated that low-dose As2O3 had the same effect as the conventional dosage and the mechanism of low- dose arsenic seemed to primarily induce differentiation of APL cells.