S
Saira Ahmed
Researcher at University of Texas MD Anderson Cancer Center
Publications - 110
Citations - 3421
Saira Ahmed is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 20, co-authored 25 publications receiving 3074 citations. Previous affiliations of Saira Ahmed include University of Texas Health Science Center at Houston & University of Manchester.
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Journal ArticleDOI
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Yutaka Kondo,Lanlan Shen,Alfred S. L. Cheng,Alfred S. L. Cheng,Saira Ahmed,Yanis Boumber,Chantale Charo,Tadanori Yamochi,Takeshi Urano,Koichi Furukawa,Bernard Kwabi-Addo,David Gold,Yoshitaka Sekido,Tim H M Huang,Jean Pierre J. Issa +14 more
TL;DR: Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation.
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Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
Lanlan Shen,Minoru Toyota,Yutaka Kondo,Edward H. Lin,Li Zhang,Yi Guo,Natalie Supunpong Hernandez,Xinli Chen,Saira Ahmed,Kazuo Konishi,Stanley R. Hamilton,Jean Pierre J. Issa +11 more
TL;DR: Together, the integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease.
Journal ArticleDOI
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
Lanlan Shen,Yutaka Kondo,Yi Guo,Jiexin Zhang,Li Zhang,Saira Ahmed,Jingmin Shu,Xinli Chen,Robert A. Waterland,Jean Pierre J. Issa +9 more
TL;DR: A group of non-X–linked bona fide promoter CpG islands that are densely methylated in normal somatic tissues, escape methylation in germline cells, and for which DNA methylation is a primary mechanism of tissue-specific gene silencing are identified.
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DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes
Lanlan Shen,Hagop Kantarjian,Yi Guo,E. Lin,Jianqin Shan,Xuelin Huang,Donald A. Berry,Saira Ahmed,Wei Zhu,Sherry Pierce,Yutaka Kondo,Yasuhiro Oki,Jaroslav Jelinek,Hussain I. Saba,Eli Estey,Jean Pierre J. Issa +15 more
TL;DR: Although methylation at baseline did not correlate with clinical response to decitabine, a significant correlation between reduced methylation over time and clinical responses was observed.
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Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.
Yutaka Kondo,Lanlan Shen,Saira Ahmed,Yanis Boumber,Yoshitaka Sekido,Bassem R. Haddad,Jean Pierre J. Issa +6 more
TL;DR: RNAi-based inhibition of HMTs in PC3 cancer cell line markedly inhibited cell growth and caused profound morphological changes with loss of telomerase activity and shortened telomeres, suggesting that the 2 H MTs, SUV39H1 and G9a are required to perpetuate the malignant phenotype.