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Bernard Kwabi-Addo
Researcher at Howard University
Publications - 52
Citations - 3303
Bernard Kwabi-Addo is an academic researcher from Howard University. The author has contributed to research in topics: DNA methylation & Prostate cancer. The author has an hindex of 22, co-authored 50 publications receiving 3111 citations. Previous affiliations of Bernard Kwabi-Addo include Baylor College of Medicine & University of Washington.
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Journal ArticleDOI
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Yutaka Kondo,Lanlan Shen,Alfred S. L. Cheng,Alfred S. L. Cheng,Saira Ahmed,Yanis Boumber,Chantale Charo,Tadanori Yamochi,Takeshi Urano,Koichi Furukawa,Bernard Kwabi-Addo,David Gold,Yoshitaka Sekido,Tim H M Huang,Jean Pierre J. Issa +14 more
TL;DR: Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation.
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The role of fibroblast growth factors and their receptors in prostate cancer
TL;DR: The effects of increased FGF receptor signaling are wide ranging and involve both the cancer cells and surrounding stroma, including the vasculature, all of which can enhance tumor progression and clinical aggressiveness.
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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Bernard Kwabi-Addo,Dipak Giri,Karen Schmidt,Katrina Podsypanina,Ramon Parsons,Norman M. Greenberg,Michael Ittmann +6 more
TL;DR: Analysis of prostate cancer progression in transgenic adenocarcinoma of mouse prostate mice bred to Pten+/− heterozygous mice, coupled with analysis of the Pten gene and protein in the resulting tumors, reveals that haploinsufficiency of thePten gene promotes the progression of prostatecancer in this model system.
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A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.
Andrew J.H. Smith,De Sousa Ma,Bernard Kwabi-Addo,Amanda C. Heppell-Parton,Helen Impey,Pamela Rabbitts +5 more
TL;DR: A strategy for chromosome engineering in embryonic stem (ES) cells that relies on sequential gene targeting and Cre–loxP site–specific recombination and will allow the design of a variety of chromosome rearrangements that can be selected and verified in ES cells or activated in ES cell–derived mice.
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Age-related DNA methylation changes in normal human prostate tissues
Bernard Kwabi-Addo,Woonbok Chung,Lanlan Shen,Michael Ittmann,Thomas M. Wheeler,Jaroslav Jelinek,Jean Pierre J. Issa +6 more
TL;DR: The findings show aberrant hypermethylation as a function of age in the normal prostate tissues, which may precede and predispose to full-blown malignancy.