S
Sally A. Cowley
Researcher at University of Oxford
Publications - 121
Citations - 8542
Sally A. Cowley is an academic researcher from University of Oxford. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 34, co-authored 100 publications receiving 6925 citations. Previous affiliations of Sally A. Cowley include Royal College of Surgeons of England & Institute of Cancer Research.
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Journal ArticleDOI
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
TL;DR: Results show that, depending on cellular context, activation of MAP kinase kinase is necessary and sufficient for cell differentiation or proliferation.
Journal ArticleDOI
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
Norman W. Freshney,Lesley Rawlinson,F Guesdon,Elizabeth Jones,Sally A. Cowley,J. Justin Hsuan,J Saklatvala +6 more
TL;DR: An IL-1-stimulated protein kinase cascade resulting in phosphorylation of the small heat shock protein hsp27 has been identified in KB cells and p40 and p50 resembled MAPKAPK-2 and may be identical.
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Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
Dario R. Alessi,Y. Saito,David G. Campbell,Philip Cohen,G. Sithanandam,U. Rapp,A. Ashworth,C.J. Marshall,Sally A. Cowley +8 more
TL;DR: Analysis of MAPKK1 mutants in which either Ser217 or Ser221 were changed to glutamic acid, and the finding that inactivation of maximally activatedMAPKK1 required the dephosphorylated of both serines, shows that phosphorylation of either residue is sufficient for maximal activation.
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
Walther Haenseler,Stephen N. Sansom,Julian Buchrieser,Sarah E. Newey,Craig S. Moore,Francesca J. Nicholls,Satyan Chintawar,Christian Schnell,Jack P. Antel,Nicholas D. Allen,M Z Cader,Richard Wade-Martins,William James,Sally A. Cowley +13 more
TL;DR: Co-culture microglia downregulate pathogen-response pathways, upregulate homeostatic function pathways, and promote a more anti-inflammatory and pro-remodeling cytokine response than corresponding monocultures, demonstrating that co-cultures are preferable for modeling authentic microglial physiology.
Journal ArticleDOI
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
Hugo J. R. Fernandes,Elizabeth M. Hartfield,Helen C. Christian,Evangelia Emmanoulidou,Ying Zheng,Heather D.E. Booth,Helle Bogetofte,Helle Bogetofte,Charmaine Lang,Brent J. Ryan,S. Pablo Sardi,Jennifer Badger,Jane Vowles,Samuel Evetts,George K. Tofaris,Kostas Vekrellis,Kevin Talbot,Michele T.M. Hu,William James,Sally A. Cowley,Richard Wade-Martins +20 more
TL;DR: Overall, ER stress, autophagic/lysosomal perturbations, and elevated extracellular α-synuclein likely represent critical early cellular phenotypes of PD, which might offer multiple therapeutic targets.