J
J. Justin Hsuan
Researcher at University College London
Publications - 99
Citations - 14962
J. Justin Hsuan is an academic researcher from University College London. The author has contributed to research in topics: Kinase & Phosphatidylinositol. The author has an hindex of 55, co-authored 99 publications receiving 14599 citations. Previous affiliations of J. Justin Hsuan include National Institutes of Health & National Institute for Medical Research.
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Journal ArticleDOI
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
Norman W. Freshney,Lesley Rawlinson,F Guesdon,Elizabeth Jones,Sally A. Cowley,J. Justin Hsuan,J Saklatvala +6 more
TL;DR: An IL-1-stimulated protein kinase cascade resulting in phosphorylation of the small heat shock protein hsp27 has been identified in KB cells and p40 and p50 resembled MAPKAPK-2 and may be identical.
Journal ArticleDOI
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.
Peter J. Jose,David A. Griffiths-Johnson,Peter Collins,D. T. Walsh,Redwan Moqbel,N F Totty,O. Truong,J. Justin Hsuan,Timothy J. Williams +8 more
TL;DR: Eotaxin was found to be a potent stimulator of both guinea pig and human eosinophils in vitro and suggests the possibility that similar molecules may be important in the human asthmatic lung.
Journal ArticleDOI
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.
Mark A. Marchionni,Andrew Goodearl,Maio Su Chen,Olivia Bermingham-McDonogh,Cassandra Kirk,Marvin Hendricks,Frank Danehy,Don Misumi,Judith Sudhalter,Kazumi Kobayashi,Diana Wroblewski,Catherine Lynch,Mark Baldassare,Ian Hiles,John B. Davis,John B. Davis,J. Justin Hsuan,Nicholas F. Totty,Masayuki Otsu,Robert N. McBurney,Michael D. Waterfield,Paul Stroobant,David I. Gwynne +22 more
TL;DR: Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain.
Journal ArticleDOI
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.
Masayuki Otsu,Ian Hiles,Ivan Gout,Michael J. Fry,Fernanda Ruiz-Larrea,George Panayotou,Andrew J. Thompson,Ritu Dhand,J. Justin Hsuan,Nicholas F. Totty,Anthony D. Smith,Sarah J. Morgan,Sara A. Courtneidge,Peter J. Parker,Michael D. Waterfield +14 more
TL;DR: The active PI3-kinase complex containing p85 alpha or p85 beta and the 110 kd protein binds to PDGF but not EGF receptors, suggesting that p85alpha and p85beta may mediate specific PI3 -kinase interactions with a subset of tyrosine kinases.
Journal ArticleDOI
Phosphatidylinositol 3-kinase : structure and expression of the 110 kd catalytic subunit
Ian Hiles,Masayuki Otsu,Stefano Volinia,Michael J. Fry,Ivan Gout,Ritu Dhand,George Panayotou,Fernanda Ruiz-Larrea,Andrew J. Thompson,Nicholas F. Totty,J. Justin Hsuan,Sara A. Courtneidge,Peter J. Parker,Michael D. Waterfield,Michael D. Waterfield +14 more
TL;DR: The characterization of the p110 subunit of Purified bovine brain phosphatidylinositol 3-kinase reveals p110 to be a 1068 aa protein related to Vps34p, a S. cerevisiae protein involved in the sorting of proteins to the vacuole.