S
Salvatore Condello
Researcher at Indiana University
Publications - 53
Citations - 1932
Salvatore Condello is an academic researcher from Indiana University. The author has contributed to research in topics: Ovarian cancer & Stem cell. The author has an hindex of 22, co-authored 47 publications receiving 1454 citations. Previous affiliations of Salvatore Condello include Northwestern University & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells
Junjie Li,Salvatore Condello,Jessica Thomes-Pepin,Xiaoxiao Ma,Yu Xia,Thomas D. Hurley,Daniela Matei,Daniela Matei,Ji-Xin Cheng +8 more
TL;DR: It is shown that increased lipid unsaturation is a metabolic marker for ovarian CSCs and a target for CSC-specific therapy and Mechanistically, it is demonstrated that nuclear factor κB (NF-κB) directly regulates the expression levels of lipid desaturases, and inhibition of desaturase blocks NF-κBs signaling.
Journal ArticleDOI
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
Salvatore Condello,Cynthia A. Morgan,Sarbajeet Nagdas,Liyun Cao,John J. Turek,Thomas D. Hurley,Daniela Matei +6 more
TL;DR: In this paper, the role of β-catenin-regulated ALDH1A1 in the maintenance of ovarian cancer spheroids was investigated and new targetable molecules targeting this cell population were proposed.
Journal ArticleDOI
Epigenetic targeting of ovarian cancer stem cells.
Yinu Wang,Horacio Cardenas,Fang Fang,Salvatore Condello,Pietro Taverna,Matthew W. Segar,Yunlong Liu,Kenneth P. Nephew,Daniela Matei +8 more
TL;DR: In this paper, the effects of the new DNA methytransferase inhibitor SGI-110 on cancer stem-like marker aldehyde dehydrogenase (ALDH) were evaluated.
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids
Salvatore Condello,Cynthia A. Morgan,Sarbajeet Nagdas,Liyun Cao,John J. Turek,Thomas D. Hurley,Daniela Matei +6 more
TL;DR: The role of β-catenin-regulated ALDH1A1 in the maintenance of OC spheroids is supported and new ALDH 1A1 inhibitors targeting this cell population are proposed.
Journal ArticleDOI
Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis.
Yinu Wang,Guangyuan Zhao,Salvatore Condello,Hao Huang,Horacio Cardenas,Edward J. Tanner,Jian-Jun Wei,Yanrong Ji,Junjie Li,Yuying Tan,Ramana V. Davuluri,Marcus E. Peter,Ji-Xin Cheng,Daniela Matei,Daniela Matei +14 more
TL;DR: The results support the existence of a platinum-tolerant cell population with partial cancer stem cell features, characterized by FZD7 expression and dependent on the FzD7–β-catenin–Tp63–GPX4 pathway for survival.