Hao Huang

TL;DR: It is shown that FTO, as an m6A demethylase, plays a critical oncogenic role in acute myeloid leukemia (AML) and provides profound insights into leukemogenesis and drug response.

TL;DR: It is suggested that intracellular S1P produced in response to RANKL forms a negative feedback loop in BMM single cultures and plays an important role in osteoclastogenesis regulation and in communication between osteoclasts and osteoblasts or T cells.

TL;DR: The results implicate the HMGA2–TET1–HOX signaling pathway in the epigenetic regulation of human breast cancer and highlight the importance of targeting methylation in specific subpopulations as a potential therapeutic strategy.

TL;DR: It is suggested that IL-17 can function as a signal to induce extensive bone turnover by regulating hMSC recruitment, proliferation, motility, and differentiation by supporting osteoclastogenesis both in vivo and in vitro.

TL;DR: In contrast to the frequent down-regulation (or loss-of-function mutations) and critical tumor-suppressor roles of the three TET genes observed in various types of cancers, here it is shown that TET1 is a direct target of MLL-fusion proteins and is significantly up-regulated in M LL-rearranged leukemia, leading to a global increase of 5-hydroxymethylcytosine level.