Debra Rimmington

TL;DR: It is shown—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor.

TL;DR: GDF15 expression is regulated by the integrated stress response and is induced in selected tissues in mice in these settings, and it is demonstrated that pharmacological GDF15 administration to mice can trigger conditioned taste aversion, suggesting that GDF 15 may induce an aversive response to nutritional stress.

TL;DR: It is found that the obese-“on” state is characterized by reduced expression of an imprinted gene network including Nnat, Peg3, Cdkn1c, and Plagl1 and that independent targeting of these alleles recapitulates the stochastic bi-stable disease phenotype.

TL;DR: The data suggest that Fto may have a critical role in the control of lean mass, independent of its effect on food intake, and sterotactically injected adeno-associated viral vectors encoding Cre recombinase to cause regional deletion observed a small reduction in food intake and weight gain with no effect on energy expenditure or body composition.

TL;DR: The data reveal arcuate POMC neurons to be a highly heterogeneous population, each with distinct cell surface receptor gene expression profiles.