N
Neil Grimsey
Researcher at University of Georgia
Publications - 40
Citations - 1931
Neil Grimsey is an academic researcher from University of Georgia. The author has contributed to research in topics: G protein-coupled receptor & Signal transduction. The author has an hindex of 17, co-authored 32 publications receiving 1638 citations. Previous affiliations of Neil Grimsey include University of California, San Diego & University of Cambridge.
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Journal ArticleDOI
The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.
Helena Santos-Rosa,Joanne Leung,Neil Grimsey,Sew Y. Peak-Chew,Symeon Siniossoglou,Symeon Siniossoglou +5 more
TL;DR: It is shown that Smp2, the yeast homologue of mammalian lipin, is a key regulator of nuclear membrane growth during the cell cycle and associates with the promoters of phospholipid biosynthetic enzymes in a Nem1–Spo7‐dependent manner.
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Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection
Maurizio Renna,Catherine Schaffner,Karen Brown,Shaobin Shang,Marcela Henao Tamayo,Krisztina Hegyi,Neil Grimsey,David Cusens,Sarah Coulter,Jason D. Cooper,Anne R. Bowden,Sandra M. Newton,Beate Kampmann,Jennifer Helm,Andrew Jones,Charles S. Haworth,Randall J. Basaraba,Mary Ann DeGroote,Diane J. Ordway,David C. Rubinsztein,R. Andres Floto +20 more
TL;DR: It is found that in primary human macrophages, concentrations of azithromycin achieved during therapeutic dosing blocked autophagosome clearance by preventing lysosomal acidification, thereby impairing autophagic and phagosomal degradation and resulted in chronic infection with NTM in mice.
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Control of Phospholipid Synthesis by Phosphorylation of the Yeast Lipin Pah1p/Smp2p Mg2+-dependent Phosphatidate Phosphatase
TL;DR: Genetic analysis suggests that Pah1p regulates transcription of these genes through both Opi1p-dependent and -independent mechanisms, and provides evidence that derepression of phospholipid biosynthetic genes is not sufficient to induce the nuclear membrane expansion shown in the pah1Δ cells.
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The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
Victoria A. Payne,Neil Grimsey,Antoinette Tuthill,Sam Virtue,Sarah L. Gray,Edoardo Dalla Nora,Robert K. Semple,Stephen O'Rahilly,Justin J. Rochford +8 more
TL;DR: This study demonstrates that BSCL2 is an essential, cell-autonomous regulator of adipogenesis, and the induction of BSCL1 expression was essential for adipogenesis to occur.
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Temporal and Spatial Regulation of the Phosphatidate Phosphatases Lipin 1 and 2
Neil Grimsey,Gil-Soo Han,Laura O'Hara,Justin J. Rochford,George M. Carman,Symeon Siniossoglou +5 more
TL;DR: The functions of lipin 1 and 2 are evolutionarily conserved from unicellular eukaryotes to mammals and it is proposed that distinct and non-redundant functions of lipid production during the cell cycle and adipocyte differentiation are proposed.