Amanda J Lewis

TL;DR: Using three-dimensional correlative light and electron microscopy of Lewy bodies and Lewy neurites in postmortem brains of Parkinson’s disease patients, researchers show that the major constituents are membranes rather than proteinaceous filaments.

TL;DR: It is shown that pTDP-43 extracted from brain forms stable assemblies of distinct densities and morphologies that are associated with disease subtypes, consistent with the notion that disease heterogeneity could originate from alternate pathological TDP- 43 conformations, which are reminiscent of prion strains.

TL;DR: Cerebral Corpora amylacea are composed of dense labyrinth-like sheets of lipid membranes, contain vesicles as well as morphologically preserved mitochondria, and are in close proximity to blood vessels and the glymphatic system, primarily within the cytoplasm of perivascular glial cells.

TL;DR: Challenges, limitations and recent developments in the application of current EM imaging, including cryo-ET and correlative hybrid techniques, on PMHB are covered.

TL;DR: In this paper, advanced microscopy techniques were used to compare the seeding properties of pathological TDP-TDP-A and FTLD-TPD-C aggregates. And the results showed that the resulting aggregates are large and contain densely packed fibrils, reminiscent of the pure compacted Fibrils present within cytoplasmic inclusions in postmortem brains.