S
Sandhya Srinivasan
Researcher at University of Wisconsin-Madison
Publications - 8
Citations - 117
Sandhya Srinivasan is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Gene & Chloride channel activity. The author has an hindex of 3, co-authored 7 publications receiving 79 citations.
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Journal ArticleDOI
LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
Prabhjot Kaur,Marvin Rausch,Basanti Malakar,Uchenna Watson,Nikhil P Damle,Yogesh Chawla,Sandhya Srinivasan,Kanika Sharma,Tanja Schneider,Gagan Deep Jhingan,Deepak Kumar Saini,Debasisa Mohanty,Fabian Grein,Vinay Kumar Nandicoori +13 more
TL;DR: Interaction sites in the extracytoplasmic PASTA domain are identified and it is shown that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis and cell death.
Journal ArticleDOI
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy
Divya Sinha,Benjamin Steyer,Pawan K Shahi,Katherine P. Mueller,Rasa Valiauga,Kimberly L. Edwards,Cole Bacig,Stephanie S. Steltzer,Sandhya Srinivasan,Amr A. Abdeen,Evan Cory,Viswesh Periyasamy,Alireza Fotuhi Siahpirani,Edwin M. Stone,Budd A. Tucker,Sushmita Roy,Bikash R. Pattnaik,Krishanu Saha,David M. Gamm +18 more
TL;DR: The results suggest that gene augmentation is a viable first-line approach for some individuals with dominant Best disease and that non-responders are candidates for alternate approaches such as gene editing, however, testing gene editing strategies for on-target efficiency and off-target events using personalized iPSC-RPE model systems is warranted.
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Mycobacterium tuberculosis Reactivates HIV-1 via Exosome-Mediated Resetting of Cellular Redox Potential and Bioenergetics.
Priyanka Tyagi,Priyanka Tyagi,Virender Kumar Pal,Ragini Agrawal,Shalini Singh,Sandhya Srinivasan,Amit Singh +6 more
TL;DR: Exosomes secreted by macrophages infected with M. tuberculosis, including drug-resistant clinical strains, reactivated HIV-1 by inducing oxidative stress, revealing new paradigms for understanding the redox and bioenergetics bases of HIV-M.
Journal ArticleDOI
Switch to autophagy the key mechanism for trabecular meshwork death in severe glaucoma.
Aparna Rao,Aparna Rao,Prity Sahay,Prity Sahay,Munmun Chakraborty,Munmun Chakraborty,Birendra Kumar Prusty,Sandhya Srinivasan,Gagan Deep Jhingan,Pragyan Mishra,Rahul Modak,Mrutyunjay Suar +11 more
TL;DR: A preference of autophagy over apoptosis may be underlie the mechanism of stage transition from moderate to severe glaucoma in the trabecular meshwork or peripheral blood which may be tightly regulated by epigenetic modulators.
Posted ContentDOI
Human iPSC modeling elucidates mutation-specific responses to gene therapy in a genotypically diverse dominant maculopathy
Divya Sinha,Benjamin Steyer,Pawan K Shahi,Katherine P. Mueller,Rasa Valiauga,Kimberly L. Edwards,Cole Bacig,Stephanie S. Steltzer,Sandhya Srinivasan,Amr A. Abdeen,Evan Cory,Viswesh Periyasamy,Alireza Fotuhi Siahpirani,Edwin M. Stone,Edwin M. Stone,Budd A. Tucker,Budd A. Tucker,Sushmita Roy,Bikash R. Pattnaik,Krishanu Saha,David M. Gamm +20 more
TL;DR: GA is a viable approach for a subset of adBD patients depending on the functional role of the mutated residue, and GA non-responders are candidates for targeted CRISPR-Cas9 GE of the mutant allele.