S
Sandra Blanco
Researcher at University of Salamanca
Publications - 42
Citations - 3812
Sandra Blanco is an academic researcher from University of Salamanca. The author has contributed to research in topics: RNA & Cancer. The author has an hindex of 29, co-authored 41 publications receiving 2899 citations. Previous affiliations of Sandra Blanco include University of Cambridge & Wellcome Trust Centre for Stem Cell Research.
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Journal ArticleDOI
Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders
Sandra Blanco,Sabine Dietmann,Joana V. Flores,Shobbir Hussain,Claudia Kutter,Peter Humphreys,Margus Lukk,Patrick Lombard,Lucas Treps,Martyna C. Popis,Stefanie Kellner,Sabine M. Hölter,Lillian Garrett,Wolfgang Wurst,Lore Becker,Thomas Klopstock,Helmut Fuchs,Valerie Gailus-Durner,Martin Hrabĕ de Angelis,Ragnhildur Thóra Káradóttir,Mark Helm,Jernej Ule,Joseph G. Gleeson,Duncan T. Odom,Michaela Frye +24 more
TL;DR: It is found that loss of cytosine‐5 RNA methylation increases the angiogenin‐mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading to an accumulation of 5′ tRNA‐derived small RNA fragments, and failure in NSun2‐mediated tRNA methylation contributes to human diseases via stress‐induced RNA cleavage.
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NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs
Shobbir Hussain,Abdulrahim A. Sajini,Sandra Blanco,Sabine Dietmann,Patrick Lombard,Yoichiro Sugimoto,Maike Paramor,Joseph G. Gleeson,Duncan T. Odom,Jernej Ule,Jernej Ule,Michaela Frye +11 more
TL;DR: It is shown that loss of cytosine-5 methylation in vault RNAs causes aberrant processing into Argonaute-associated small RNA fragments that can function as microRNAs, and impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders.
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Stem cell function and stress response are controlled by protein synthesis
Sandra Blanco,Roberto Bandiera,Martyna C. Popis,Shobbir Hussain,Patrick Lombard,Jelena Aleksic,Abdulrahim A. Sajini,Hinal Tanna,Rosana Cortés-Garrido,Nikoletta A. Gkatza,Sabine Dietmann,Michaela Frye +11 more
TL;DR: It is shown that skin stem cells synthesize less protein than their immediate progenitors in vivo, even when forced to proliferate, and inhibition of post-transcriptional cytosine-5 methylation locks stem cells in this distinct translational inhibition programme.
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Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome
Fernando J. Martinez,Jeong Ho Lee,Jieun Lee,Sandra Blanco,Elizabeth Nickerson,Stacey Gabriel,Michaela Frye,Lihadh Al-Gazali,Joseph G. Gleeson +8 more
TL;DR: The findings establish NSUN2 as the first causal gene with relationship to the DS spectrum phenotype, which might help explain the varied clinical presentation in DS that can include chromosomal instability and immunological defects.
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Characterizing 5-methylcytosine in the mammalian epitranscriptome
TL;DR: Transcriptome-wide approaches to capture the global m5C RNA methylome are described and the potential functions of m 5C in RNA and compare them to 6-methyladenosine modifications are discussed.