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Claudia Kutter
Researcher at Science for Life Laboratory
Publications - 54
Citations - 6080
Claudia Kutter is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 25, co-authored 45 publications receiving 5240 citations. Previous affiliations of Claudia Kutter include University of Cambridge & Leibniz Association.
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Journal ArticleDOI
The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
Nuno L. Barbosa-Morais,Nuno L. Barbosa-Morais,Manuel Irimia,Qun Pan,Hui Yuan Xiong,Serge Gueroussov,Leo J. Lee,Valentina Slobodeniuc,Claudia Kutter,Stephen Watt,Recep Colak,TaeHyung Kim,Christine M. Misquitta-Ali,Michael D. Wilson,Michael D. Wilson,Philip M. Kim,Duncan T. Odom,Duncan T. Odom,Brendan J. Frey,Benjamin J. Blencowe +19 more
TL;DR: The findings suggest that the evolution of alternative splicing has for the most part been very rapid and thatAlternative splicing patterns of most organs more strongly reflect the identity of the species rather than the organ type, with the highest complexity in primates.
Journal ArticleDOI
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding
Dominic Schmidt,Michael D. Wilson,Benoit Ballester,Petra C. Schwalie,Gordon D. Brown,Aileen Marshall,Claudia Kutter,Stephen Watt,Celia P. Martinez-Jimenez,Sarah Mackay,Iannis Talianidis,Paul Flicek,Paul Flicek,Duncan T. Odom +13 more
TL;DR: Large interspecies differences in transcriptional regulation and insight into regulatory evolution are revealed and revealed in livers of five vertebrates.
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Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression.
Anna Git,Heidi Dvinge,Mali Salmon-Divon,Michelle Osborne,Claudia Kutter,James Hadfield,Paul Bertone,Carlos Caldas +7 more
TL;DR: This work analyzed three biological samples across six miRNA microarray platforms and compared their hybridization performance, and validated the results for 89 miRNAs by real-time RT-PCR and challenged the use of this assay as a "gold standard."
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Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages.
Dominic Schmidt,Petra C. Schwalie,Michael D. Wilson,Benoit Ballester,Ângela Gonçalves,Claudia Kutter,Gordon D Brown,Aileen Marshall,Paul Flicek,Paul Flicek,Duncan T. Odom,Duncan T. Odom +11 more
TL;DR: The full spectrum of CTCF-binding sites was defined, including a 33/34-mer motif, and over five thousand highly conserved, robust, and tissue-independent CTCf-binding locations were identified by comparing ChIP-seq data from six mammals.
Journal ArticleDOI
Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders
Sandra Blanco,Sabine Dietmann,Joana V. Flores,Shobbir Hussain,Claudia Kutter,Peter Humphreys,Margus Lukk,Patrick Lombard,Lucas Treps,Martyna C. Popis,Stefanie Kellner,Sabine M. Hölter,Lillian Garrett,Wolfgang Wurst,Lore Becker,Thomas Klopstock,Helmut Fuchs,Valerie Gailus-Durner,Martin Hrabĕ de Angelis,Ragnhildur Thóra Káradóttir,Mark Helm,Jernej Ule,Joseph G. Gleeson,Duncan T. Odom,Michaela Frye +24 more
TL;DR: It is found that loss of cytosine‐5 RNA methylation increases the angiogenin‐mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading to an accumulation of 5′ tRNA‐derived small RNA fragments, and failure in NSun2‐mediated tRNA methylation contributes to human diseases via stress‐induced RNA cleavage.