Sandra M. Cardoso

TL;DR: Clinical and biochemical features shared by AD and diabetes, giving special attention to the involvement of mitochondria are discussed, particularly mitochondrial target antioxidants and Szeto-Schiller peptides.

TL;DR: Design, synthesis and evaluation of new tacrine-benzofuran hybrids as multitargeting anti- Alzheimer’s disease agents; high AChE inhibition associated with other relevant properties; structure–activity relationship analysis.

TL;DR: Eleven new hybrid compounds developed and evaluated for chemical and biological properties showed neuroprotective effects in neuronal cells subjected to model stressors of AD, but not significant dependence on the substituent groups, and evidenced drug-likeness properties, including good membrane permeability.

TL;DR: The literature is reviewed and discussed on how LRRK2 affects mitochondrial function, autophagy, and microtubule dynamics and how this is implicated in the PD etiology.

TL;DR: Evidence suggesting a clear association between mitochondrial dysfunction, autophagy impairment and amyloid-beta accumulation in Alzheimer's disease pathophysiology is discussed and an innovative window for new therapeutic strategies aimed to activate or ameliorate macroautophagy may be opened.