Showing papers in "Journal of Inorganic Biochemistry in 2018"

TL;DR: An overview of current knowledge of the structure, flexibility, and interactions with substrates and redox partners of cytochrome P450 on membranes is provided, amalgamating information derived from both experiments and simulations.

TL;DR: This study provided a good model to know about the dynamic process of lead(II)-induced autophagy in rPT cells, and the interplay between autophagic degradation and apoptosis highlights a new sight into the mechanism of lead (II)induced nephrotoxicity.

TL;DR: Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone derivatives have been synthesized and their structural and biological characteristics have been compared with those of the known analogs.

TL;DR: Analysis of the equilibrium constants of the reactions and spectroscopic data has allowed determination of the type of coordination and effectiveness of the carboxyl groups in the process of complex formation.

TL;DR: H2O2-dependent inhibition of human P450s has been studied in the laboratory, demonstrating heme destruction and also the inactivating oxidation of the heme-thiolate ligand to a sulfenic acid (-SOH).

TL;DR: It is speculated that arsenic or copper could induce oxidative stress, inflammation and autophagy in chicken brains, and there may have a synergistic effect between copper and arsenic.

TL;DR: Investigation of how functional diversity within superfamilies of metalloenzymes relates to structural changes at the catalytic metal site finds that there are no examples in the dataset where metal sites with a redox role are lost during evolution.

TL;DR: A combination of isothermal titration calorimetry and multinuclear NMR spectroscopy is used to investigate interactions among the components of the biological machine that carries out the assembly of iron-sulfur clusters in human mitochondria.

TL;DR: Data from this study are consistent with a novel biological role of metHb as a H2S carrier in the blood, in parallel with the oxygen carrier function of the much more abundant ferrous Hb.

TL;DR: The results suggest that Lut suppress HgCl2-induced renal injury via activation of Nrf2 signaling pathway, and reduces renal mercuric accumulation in rat.

TL;DR: Four new complexes synthesized and characterized showed that all complexes exert moderate to high selective cytotoxicity, inducing apoptosis and autophagy in HeLa and PANC-1 tumor cell lines.

TL;DR: These complexes are found to be active against different cancer cell lines with half maximal inhibitory concentration (IC50) values between 1 and 5 μM, and exhibit very good Deoxyribonucleic acid (DNA) binding properties, which is a probable reason for their high cytotoxicity.

TL;DR: Results indicated that miR-193b-3p is involved in broiler hepatocyte apoptosis in Se deficiency by regulating the target protein MAML1.

TL;DR: AGSAL-1 is a candidate towards the development on a new efficient medication of the silver based metallodrugs for wounds healing and its genotoxicity was evaluated using Allium cepa model, in vivo.

TL;DR: A comparative analysis of the cytotoxic effect of the compounds on a panel of human cancer cell lines showed that the copper complexes exhibited in vitro antitumor activity significantly higher than that of the free ligands and also of cisplatin.

TL;DR: Modification of tumor cell proteins by HOCl enhances the establishment of a T cell response and thus might be involved in immunogenic modulation, and targeting the control of HOCl signaling system should allow one to establish novel rational therapeutic approaches.

TL;DR: Investigation of the kinetics of the direct metabolism of six phytocannabinoids by CYP2J2 shows that they are potent inhibitors of CYP 2J2-mediated AEA metabolism, with Δ9-THC being the strongest inhibitor.

TL;DR: 1a and 4a are the first crystallographically reported ruthenium compounds with acylthiourea coordinated via S and N(amide) atoms, and their cytotoxic properties were evaluated in human lung cells.

TL;DR: Eleven new hybrid compounds developed and evaluated for chemical and biological properties showed neuroprotective effects in neuronal cells subjected to model stressors of AD, but not significant dependence on the substituent groups, and evidenced drug-likeness properties, including good membrane permeability.

TL;DR: The mass spectrometry-based interaction studies, involving selected sulfur-containing biomolecules and small model proteins, revealed pro-oxidant effects of complexes 1 and 4 and differences in stability of both complexes in the mixtures containing the model protein cytochrome c after 24h incubation.

TL;DR: Substantial supplementation with α-LA protected kidney cells from Cd-induced cytotoxicity by reducing MDA levels and Cd content, restoring endogenous enzyme activities, renewing mitochondrial function, and preventing activation of the mitochondria apoptosis pathway.

TL;DR: All formulations of GdLip, irrespectively of composition, were characterized by relaxivities higher than those of commercially used contrast agents (e.g. Magnevist®).

TL;DR: The comparison of the coordination chemistry of V-containing-haloperoxidases of the trigonal bipyramidal geometry was done by data mining and shows that the active site is very tightly regulated with only minor changes in the coordination geometry.

TL;DR: The antiproliferative activity of the gold complex [Au(tpp)Cl] (1) (tpp=triphenyphosphine) against human breast adenocarcinoma cells and normal human fetal lung fibroblast cells was investigated and it was confirmed that the complex has no in vitro toxicity.

TL;DR: Results show that ruthenium dendrimers associated with anticancer siRNA have the ability to deliver siRNA as non-viral vectors into the cancer cells and can protect siRNA against nuclease degradation.

TL;DR: The results indicate that the possibility to tailor the composition of the coatings provides materials able to modulate bone growth and bone resorption.

TL;DR: The cell proliferation assays show that the Δ form induces a greater cytotoxicity than the Λ form on human cervical cancer HeLa cells, which implies that the DNA binding affinities of ruthenium(II) polypyridyl complexes might be constitute to the part of their anticancer mechanisms.

TL;DR: Protein models based on the crystal structure data of MroUPO (Marasmius rotula unspecific peroxygenase) revealed that the bulky cortisone molecule suitably fits into the enzyme's access channel, which enables the heme iron to come in close contact to the carbons of the steroidal side chain.

TL;DR: All the NHC precursors displayed significantly lower biological activities compared with their respective complexes, indicating the utility of silver(I) ions in antimicrobial and antilung cancer applications.

TL;DR: Citronellal, vanillin and pyridoxal thiosemicarbazones were modified with polar substituents, namely ethylmorpholine and glucose, to increase their polarity and compare the effects of these moieties on their biological activity.