Sandra Menke

TL;DR: The aim of this study was to characterize the cardiac differentiation potential of a murine iPS cell clone in comparison to a well-established murine ES cell line, and found that iPS cells differentiate into functional cardiomyocytes.

TL;DR: A first proof of concept study evaluates the potential of a murine iPSC-derived cardiovascular progenitor population, which expresses the surface marker foetal liver kinase-1 (Flk-1), to restore myocardial tissue and improve cardiac function after acuteMyocardial infarction (MI) in mice and paves the way for an autologous i PSC-based therapy of MI.

TL;DR: A robust approach for efficient endothelial differentiation of hiPSCs in scalable suspension culture is developed, which results in relevant numbers of ECs for regenerative approaches and industrial applications that show in vitro proliferation capacity and a high degree of chromosomal stability.

TL;DR: The results demonstrate the differentiation of AT2-like cells from mESCs after serum-induction and under serum-free conditions and will facilitate the identification of key differentiation factors leading to a more specific and effective generation of AT1- like cells from ESCs.

TL;DR: Culture and expansion of nondifferentiated human embryonic stem cells (hESCs) depended on coculture with murine embryonic fibroblasts because mice are known to harbor a variety of pathogens, and such culture conditions implicate the risk of xenozoonoses.