K
Kristin Schwanke
Researcher at Hannover Medical School
Publications - 33
Citations - 2092
Kristin Schwanke is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 18, co-authored 33 publications receiving 1888 citations. Previous affiliations of Kristin Schwanke include University of Zurich.
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Journal ArticleDOI
Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells
Christina Mauritz,Kristin Schwanke,Michael Reppel,Stefan Neef,K. Katsirntaki,Lars S. Maier,Filomain Nguemo,Sandra Menke,Moritz Haustein,Juergen Hescheler,Gerd Hasenfuss,Ulrich Martin +11 more
TL;DR: The aim of this study was to characterize the cardiac differentiation potential of a murine iPS cell clone in comparison to a well-established murine ES cell line, and found that iPS cells differentiate into functional cardiomyocytes.
Journal ArticleDOI
Generation of Induced Pluripotent Stem Cells from Human Cord Blood
Alexandra Haase,Ruth Olmer,Kristin Schwanke,Stephanie Wunderlich,Sylvia Merkert,Christian Hess,Robert Zweigerdt,Ina Gruh,Johann Meyer,Stefan Wagner,Lars S. Maier,Dong Wook Han,Silke Glage,Konstantin Miller,Philipp Fischer,Hans R. Schöler,Ulrich Martin +16 more
TL;DR: The generation of human iPSCs from cord blood (CB) as a juvenescent cell source is reported, showing characteristics typical of embryonic stem cells and can be differentiated into derivatives of all three germ layers, including functional cardiomyocytes.
Journal ArticleDOI
Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro
George Kensah,Angelica Roa Lara,Julia Dahlmann,Robert Zweigerdt,Kristin Schwanke,Jan Hegermann,David Skvorc,Anke Gawol,Azadeh Azizian,Stefan Wagner,Lars S. Maier,Andreas Krause,Gerald Dräger,Matthias Ochs,Axel Haverich,Ina Gruh,Ulrich Martin +16 more
TL;DR: BCT with contractile forces comparable with native myocardium can be generated from enriched, PSC-derived CMs, based on a novel concept of tissue formation from non-dissociated cardiac cell aggregates, which represents a major step towards clinical applicability of stem cell-based heart tissue for myocardial repair.
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Transplantation and Tracking of Human-Induced Pluripotent Stem Cells in a Pig Model of Myocardial Infarction Assessment of Cell Survival, Engraftment, and Distribution by Hybrid Single Photon Emission Computed Tomography/Computed Tomography of Sodium Iodide Symporter Transgene Expression
Christian Templin,Robert Zweigerdt,Kristin Schwanke,Ruth Olmer,Jelena-Rima Ghadri,Maximilian Y. Emmert,Ennio Müller,Silke M. Küest,Susan Cohrs,Roger Schibli,Peter W Kronen,Monika Hilbe,Andreas Reinisch,Dirk Strunk,Axel Haverich,Simon P. Hoerstrup,Thomas F. Lüscher,Philipp A. Kaufmann,Ulf Landmesser,Ulrich Martin +19 more
TL;DR: The feasibility of repeated in vivo imaging of viability and tissue distribution of cellular grafts in large animals is described for the first time and vascular differentiation and long-term engraftment of hiPSCs in a large-animal model of myocardial infarction is demonstrated.
Journal ArticleDOI
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Henning Kempf,Ruth Olmer,Alexandra Haase,Annika Franke,Emiliano Bolesani,Kristin Schwanke,Diana Robles-Diaz,Michelle Coffee,Gudrun Göhring,Gerald Dräger,Gerald Dräger,Oliver Pötz,Thomas O. Joos,Erik Martinez-Hackert,Axel Haverich,Falk F. R. Buettner,Ulrich Martin,Robert Zweigerdt +17 more
TL;DR: Modulating the bulk cell density (BCD) deterministically alters anteroposterior patterning of primitive streak (PS)-like priming of hPSCs, demonstrating a decisive, functional role of the BCD and showing its utility as a method to control lineage-specific differentiation.