Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis
Sandrine Horman,Gareth J. Browne,Ulrike Krause,J. V. Patel,Didier Vertommen,Luc Bertrand,A. Lavoinne,Louis Hue,Christopher G. Proud,Mark H. Rider +9 more
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TLDR
The activation of e EF2 kinase by AMPK, resulting in the phosphorylation and inactivation of eEF2, provides a novel mechanism for the inhibition of protein synthesis.About:
This article is published in Current Biology.The article was published on 2002-08-20 and is currently open access. It has received 449 citations till now. The article focuses on the topics: Mitogen-activated protein kinase kinase & Protein phosphorylation.read more
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TSC2 mediates cellular energy response to control cell growth and survival.
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
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AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
TL;DR: Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes.
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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
TL;DR: Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.
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AMPK in Health and Disease
TL;DR: This review looks at how AMPK integrates stress responses such as exercise as well as nutrient and hormonal signals to control food intake, energy expenditure, and substrate utilization at the whole body level and the possible role of AMPK in multiple common diseases.
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AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
TL;DR: Although best known for its effects on metabolism, AMPK has many other functions, including regulation of mitochondrial biogenesis and disposal, autophagy, cell polarity, and cell growth and proliferation.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
TL;DR: AMP-activated protein kinase and SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.
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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
TL;DR: AICAR provides direct evidence that the inhibition by AMPK of activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase also operates in intact cells, and should be a useful tool for identifying new target pathways and processes regulated by theprotein kinase cascade.
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Mammalian TOR: A Homeostatic ATP Sensor
TL;DR: It is demonstrated that the mTOR pathway is influenced by the intracellular concentration of ATP, independent of the abundance of amino acids, and that mTOR itself is an ATP sensor.
Journal ArticleDOI
5‐Aminoimidazole‐4‐Carboxamide Ribonucleoside
TL;DR: AICAR provides direct evidence that the inhibition by AMPK of activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase also operates in intact cells, and should be a useful tool for identifying new target pathways and processes regulated by theprotein kinase cascade.