S
Sandy Leung-Kuen Au
Researcher at University of Hong Kong
Publications - 20
Citations - 1617
Sandy Leung-Kuen Au is an academic researcher from University of Hong Kong. The author has contributed to research in topics: microRNA & Epigenetics. The author has an hindex of 15, co-authored 19 publications receiving 1415 citations. Previous affiliations of Sandy Leung-Kuen Au include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2.
Carmen Chak-Lui Wong,Chun-Ming Wong,Edmund Kwok–Kwun Tung,Sandy Leung-Kuen Au,Joyce Man-Fong Lee,Ronnie T.P. Poon,Kwan Man,Irene Oi-Lin Ng +7 more
TL;DR: Overexpression of miR-139 in HCC cells significantly reduced cell migration and invasion in vitro and the incidence and severity of lung metastasis from orthotopic liver tumors in mice.
Journal ArticleDOI
Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
Sandy Leung-Kuen Au,Carmen Chak-Lui Wong,Joyce Man-Fong Lee,Dorothy Ngo-Yin Fan,Felice Ho-Ching Tsang,Irene Oi-Lin Ng,Chun-Ming Wong +6 more
TL;DR: The findings suggest that EZH2 exerts its prometastatic function by way of epigenetic silencing of multiple tumor suppressor miRNAs in modulating cell motility and metastasis‐related pathways.
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Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
Carmen Chak-Lui Wong,Aki Pui-Wah Tse,Yanping Huang,Yan Ting Zhu,David Kung-Chun Chiu,Robin Kit-Ho Lai,Sandy Leung-Kuen Au,Alan Ka Lun Kai,Joyce Man-Fong Lee,Larry Lai Wei,Felice Ho-Ching Tsang,Regina Cheuk-Lam Lo,Jue Shi,Yongping Zheng,Chun-Ming Wong,Irene Oi-Lin Ng +15 more
TL;DR: The role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis is investigated, finding not only that LOXL2 was regulated by hypoxia/hypoxia‐inducible factor 1 alpha (HIF‐1α), but also that TGF‐β activated LOXL 2 transcription through mothers against decapentaplegic homolog 4 (Smad4).
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Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis.
Chun-Ming Wong,Lai Wei,Cheuk-Ting Law,Daniel W.H. Ho,Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Karen Man-Fong Sze,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng +9 more
TL;DR: SETDB1 is an oncogene that is frequently up‐regulated in human HCCs; the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB said to be essential for HCC metastatic progression.
Journal ArticleDOI
Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b
Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong +7 more
TL;DR: This study aimed to investigate the expression and functional implications of lncRNAs in human HCC and suggested the role of long non‐coding RNAs (lncRNA) in human carcinogenesis.