S
Sandy Yu
Researcher at Johns Hopkins University
Publications - 5
Citations - 1479
Sandy Yu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: AMPA receptor & Synaptic plasticity. The author has an hindex of 5, co-authored 5 publications receiving 1399 citations. Previous affiliations of Sandy Yu include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory
Hey Kyoung Lee,Kogo Takamiya,Jung-Soo Han,Heng-Ye Man,Chong Hyun Kim,Gavin Rumbaugh,Sandy Yu,Lin Ding,Chun He,Ronald S. Petralia,Robert J. Wenthold,Michela Gallagher,Richard L. Huganir +12 more
TL;DR: It is demonstrated that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories.
Journal ArticleDOI
Targeted In Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression
Jordan P. Steinberg,Kogo Takamiya,Ying Shen,Jun Xia,Maria E. Rubio,Sandy Yu,Wenying Jin,Gareth M. Thomas,David J. Linden,Richard L. Huganir +9 more
TL;DR: It is shown that targeted mutation of PICK1, the GluR2 C-terminal PDZ ligand, or the GLUR2 PKC phosphorylation site eliminates cerebellar LTD in mice and demonstrates that P Pick1-GluR1 PDZ-based interactions and Glu R2 phosphorylated are required for LTD expression in the cerebellum.
Journal ArticleDOI
Calcium-Permeable AMPA Receptor Plasticity Is Mediated by Subunit-Specific Interactions with PICK1 and NSF
Stephanie M. Gardner,Kogo Takamiya,Jun Xia,Jun Gyo Suh,Richard T. Johnson,Sandy Yu,Richard L. Huganir +6 more
TL;DR: It is found that two GluR2-interacting proteins, the PDZ domain-containing Protein interacting with C kinase (PICK1) and N-ethylmaleimide sensitive fusion protein (NSF), are specifically required for CARP.
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Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
Chong Hyun Kim,Kogo Takamiya,Ronald S. Petralia,Rita Sattler,Sandy Yu,Weiguo Zhou,Robert G. Kalb,Robert J. Wenthold,Richard L. Huganir +8 more
TL;DR: The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation, but in vivo testing indicated that the ligand is not required for CA1 hippocampusal synaptic plasticity.
Journal ArticleDOI
Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors.
Hey Kyoung Lee,Kogo Takamiya,Kimihiko Kameyama,Kaiwen He,Sandy Yu,Luciano Rossetti,David Wilen,Richard L. Huganir +7 more
TL;DR: It is demonstrated that T840 may regulate synaptic plasticity in an age-dependent manner and is phosphorylated by protein kinase C in vitro and is a highly turned-over phosphorylation site in the hippocampus.