H
Hans Acha-Orbea
Researcher at University of Lausanne
Publications - 100
Citations - 7874
Hans Acha-Orbea is an academic researcher from University of Lausanne. The author has contributed to research in topics: T cell & Mouse mammary tumor virus. The author has an hindex of 32, co-authored 97 publications receiving 7271 citations. Previous affiliations of Hans Acha-Orbea include Ludwig Institute for Cancer Research & Stanford University.
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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Pascal Schneider,Fabienne Mackay,Véronique Steiner,Kay Hofmann,Jean Luc Bodmer,Nils Holler,Christine Ambrose,Pornsri Lawton,Sarah A. Bixler,Hans Acha-Orbea,Danila Valmori,Pedro Romero,Christiane Werner-Favre,Rudolph H. Zubler,Jeffrey L. Browning,Jürg Tschopp +15 more
TL;DR: A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
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Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
Alexander Link,Tobias K. Vogt,Stéphanie Favre,Mirjam R. Britschgi,Hans Acha-Orbea,Boris Hinz,Jason G. Cyster,Sanjiv A. Luther +7 more
TL;DR: It is suggested that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4+ and CD8+ T cell homeostasis by providing a limited reservoir of survival factors.
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The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
Hans Acha-Orbea,Hugh O. McDevitt +1 more
TL;DR: It is suggested that the unique structure of the first external I-A beta chain domain is a major determinant in the disease susceptibility that maps to the major histocompatibility complex of the nonobese diabetic mouse.
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Identification of proteoglycans as the APRIL-specific binding partners
Karine Ingold,Adrian Zumsteg,Aubry Tardivel,Bertrand Huard,Quynh-Giao Steiner,Teresa G. Cachero,Fang Qiang,Leonid Gorelik,Susan L. Kalled,Hans Acha-Orbea,Paul D. Rennert,Jürg Tschopp,Pascal Schneider +12 more
TL;DR: A model whereby APRIL binding to the extracellular matrix or to proteoglycan-positive cells induces APRIL oligomerization, which is the prerequisite for the triggering of TACI- and/or BCMA-mediated activation, migration, or survival signals is proposed.
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Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.
Annette Ives,Catherine Ronet,Florence Prevel,Giulia Ruzzante,Silvia A. Fuertes-Marraco,Frédéric Schütz,Haroun Zangger,Mélanie Revaz-Breton,Lon-Fye Lye,Suzanne M. Hickerson,Stephen M. Beverley,Hans Acha-Orbea,Pascal Launois,Nicolas Fasel,Slavica Masina +14 more
TL;DR: It is shown that metastasizing parasites have a high Leishmania RNA virus–1 (LRV1) burden that is recognized by the host Toll-like receptor 3 (TLR3) to induce proinflammatory cytokines and chemokines and rendered mice more susceptible to infection, and the animals developed an increased footpad swelling and parasitemia.